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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4a2j AS0 Progesterone receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4a2j AS0Progesterone receptor / 1.300
2w8y 486Progesterone receptor / 0.903
2w8y NDRProgesterone receptor / 0.884
1sqn NDRProgesterone receptor / 0.867
2ovm AS0Progesterone receptor / 0.836
2aa2 AS4Mineralocorticoid receptor / 0.772
2aax PDNMineralocorticoid receptor / 0.765
2ab2 SNLMineralocorticoid receptor / 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2abi 1CAMineralocorticoid receptor / 0.743
2aa7 1CAMineralocorticoid receptor / 0.700
4apu A2KProgesterone receptor / 0.698
2ovh AS0Progesterone receptor / 0.686
1ya3 STRMineralocorticoid receptor / 0.681
5dx3 ESTEstrogen receptor / 0.680
4ofu DHTAndrogen receptor / 0.675
3d90 NOGProgesterone receptor / 0.672
5hyr ESTEstrogen receptor / 0.672
2oax SNLMineralocorticoid receptor / 0.667
4pxm ESTEstrogen receptor / 0.662
1gs4 ZK5Androgen receptor / 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1gwr ESTEstrogen receptor / 0.658
1y9r 1CAMineralocorticoid receptor / 0.657
3vhu SNLMineralocorticoid receptor / 0.657
2ocf ESTEstrogen receptor / 0.656
5dxg ESTEstrogen receptor / 0.656
4udc DEXGlucocorticoid receptor / 0.651