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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zm4 22T Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3zm4 22TDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.900
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4f08 1RSTyrosine-protein kinase JAK2 / 0.697
4mcv 29KProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.697
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.692
3l8p 0CEAngiopoietin-1 receptor 2.7.10.1 0.688
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.680
3lpb NVBTyrosine-protein kinase JAK2 / 0.664
2e9o A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.661
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.659
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.657