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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zku HCV Isopenicillin N synthase 1.21.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3zku HCVIsopenicillin N synthase 1.21.3.1 0.937
4bb3 KKAIsopenicillin N synthase 1.21.3.1 0.770
1odn APVIsopenicillin N synthase 1.21.3.1 0.754
1uzw CDHIsopenicillin N synthase 1.21.3.1 0.706
2jb4 A14Isopenicillin N synthase 1.21.3.1 0.705
1e26 GPBDihydrofolate reductase 1.5.1.3 0.694
1qjf ACSIsopenicillin N synthase 1.21.3.1 0.693
2ivi ACWIsopenicillin N synthase 1.21.3.1 0.689
2bjs ACVIsopenicillin N synthase 1.21.3.1 0.686
1s0j MUSTrans-sialidase / 0.684
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.680
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.676
2j41 5GPGuanylate kinase / 0.670
1hb3 SCVIsopenicillin N synthase 1.21.3.1 0.664
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.664
2plm SIB5-methylthioadenosine/S-adenosylhomocysteine deaminase 3.5.4.28 0.661
2vbd V10Isopenicillin N synthase 1.21.3.1 0.661
4kdr SAHUbiquinone biosynthesis O-methyltransferase / 0.660
3t0i SAHPutative methyltransferase / 0.659
4isu IKMGlutamate receptor 2 / 0.655
1hfp MOTDihydrofolate reductase 1.5.1.3 0.654
1obn ASVIsopenicillin N synthase 1.21.3.1 0.654
4p68 MTXDihydrofolate reductase / 0.654
3t7t SAHUncharacterized protein / 0.652
1dra MTXDihydrofolate reductase 1.5.1.3 0.650
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.650