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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vvh 4BM Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3vvh 4BMDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 1.199
3orn 3ORDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.934
1s9j BBMDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.914
4an3 5Y0Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.914
2p55 MRADual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.906
3v04 V04Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.871
3dv3 MEKDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.859
3os3 3OSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.849
4an2 EUIDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.841
4an9 2P7Dual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.832
4anb YQYDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.824
3e8n VRADual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.788
4lmn EUIDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.761
3dy7 1CXDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.750
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3sls 77DDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.689
4ubs DIFPentalenic acid synthase 1.14.15.11 0.655
4rw6 494Gag-Pol polyprotein 2.7.7.49 0.654
4kba 1QMCasein kinase I isoform delta 2.7.11.1 0.652