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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3v9l NAD Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 1.159
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.941
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.939
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.939
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.938
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.933
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.931
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.918
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.916
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.916
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.912
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.909
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.904
3b4w NADAldehyde dehydrogenase family protein / 0.903
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.895
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.884
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.879
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.877
4i8q NADPutative betaine aldehyde dehyrogenase / 0.876
2jg7 NADAntiquitin / 0.856
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.849
4pz2 NADAldehyde dehydrogenase 2-6 / 0.847
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.846
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.841
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.838
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.836
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.831
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.828
3haz NADBifunctional protein PutA / 0.824
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.822
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.809
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.798
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.798
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.790
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.789
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.788
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.786
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.777
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.772
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.760
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.759
4i8p NADAminoaldehyde dehydrogenase 1 / 0.737
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.724
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.720
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.717
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.705
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.704
4pxl NADAldehyde dehydrogenase3 / 0.698
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.693
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.684
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.682
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.681
4i3v NADAldehyde dehydrogenase (NAD+) / 0.673
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.667
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.667
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.665
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.662
1jq5 NADGlycerol dehydrogenase 1.1.1.6 0.661
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.659
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.659
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.659
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.657
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.652