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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3v8s 0HD Rho-associated protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.946
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.736
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.728
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.697
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.685
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.684
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.683
2gnh H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.680
2uzu L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.677
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.677
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.676
4agu D15Cyclin-dependent kinase-like 1 / 0.675
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
3vqh IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.670
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
3qd4 3Q63-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
1rej B1LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.668
4e1z 0MXNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.668
3qd3 3Q53-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.666
4k8a K8AFocal adhesion kinase 1 2.7.10.2 0.666
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.666
3kkv B99cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.663
1ydt IQBcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
4e5f 0N7Polymerase acidic protein / 0.660
2c1b CQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.657
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.657
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.655
2zmd 537Dual specificity protein kinase TTK 2.7.12.1 0.655
5av4 GENDeath-associated protein kinase 1 2.7.11.1 0.655
2bkz SBCCyclin-dependent kinase 2 2.7.11.22 0.651
2vth LZ2Cyclin-dependent kinase 2 2.7.11.22 0.651