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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3t42 3T4 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3t42 3T4Aldose reductase 1.1.1.21 1.055
2ikj 393Aldose reductase 1.1.1.21 0.918
2pdc 393Aldose reductase 1.1.1.21 0.914
3m64 393Aldose reductase 1.1.1.21 0.878
2pdj 393Aldose reductase 1.1.1.21 0.840
3mc5 393Aldose reductase 1.1.1.21 0.838
3ld5 LDTAldose reductase 1.1.1.21 0.823
3lz5 LDTAldose reductase 1.1.1.21 0.814
2qxw LDTAldose reductase 1.1.1.21 0.812
3ghu LDTAldose reductase 1.1.1.21 0.810
3lbo LDTAldose reductase 1.1.1.21 0.810
3lql LDTAldose reductase 1.1.1.21 0.808
2pdp 393Aldose reductase 1.1.1.21 0.805
3ghr LDTAldose reductase 1.1.1.21 0.798
3ghs LDTAldose reductase 1.1.1.21 0.798
1us0 LDTAldose reductase 1.1.1.21 0.797
2i16 LDTAldose reductase 1.1.1.21 0.797
2i17 LDTAldose reductase 1.1.1.21 0.797
2pzn 393Aldose reductase 1.1.1.21 0.797
2pdu 393Aldose reductase 1.1.1.21 0.794
2iki 388Aldose reductase 1.1.1.21 0.777
1t40 ID5Aldose reductase 1.1.1.21 0.775
3m4h 388Aldose reductase 1.1.1.21 0.763
2dux ZSTAldose reductase 1.1.1.21 0.748
2fz8 ZSTAldose reductase 1.1.1.21 0.740
2pdm ZSTAldose reductase 1.1.1.21 0.731
4yu1 53NAldose reductase 1.1.1.21 0.726
2pdx ZSTAldose reductase 1.1.1.21 0.724
1z3n 3NAAldose reductase 1.1.1.21 0.721
2duz ZSTAldose reductase 1.1.1.21 0.721
2pd5 ZSTAldose reductase 1.1.1.21 0.720
3ght LDTAldose reductase 1.1.1.21 0.716
2hvo ZSTAldose reductase 1.1.1.21 0.713
2is7 2CLAldose reductase 1.1.1.21 0.713
2inz OHPAldose reductase 1.1.1.21 0.708
2hv5 ZSTAldose reductase 1.1.1.21 0.707
3mb9 ZSTAldose reductase 1.1.1.21 0.705
4gca 2X9Aldose reductase 1.1.1.21 0.705
2hvn ZSTAldose reductase 1.1.1.21 0.701
1iei ZESAldose reductase 1.1.1.21 0.698
3m0i ZSTAldose reductase 1.1.1.21 0.698
2pdg 47DAldose reductase 1.1.1.21 0.696
2iqd LPAAldose reductase 1.1.1.21 0.686
2nvc ITAAldose reductase 1.1.1.21 0.685
2pdh 47DAldose reductase 1.1.1.21 0.684
1frb ZSTAldose reductase-related protein 2 / 0.680
2pdn 47DAldose reductase 1.1.1.21 0.677
1t41 ID5Aldose reductase 1.1.1.21 0.671
3s3g TLTAldose reductase 1.1.1.21 0.666
2pdb ZSTAldose reductase 1.1.1.21 0.662
2pdq 47DAldose reductase 1.1.1.21 0.657