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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qqh X0A Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qqh X0ACyclin-dependent kinase 2 2.7.11.22 1.037
3qqg X06Cyclin-dependent kinase 2 2.7.11.22 0.863
3qzf X66Cyclin-dependent kinase 2 2.7.11.22 0.779
3qzg X67Cyclin-dependent kinase 2 2.7.11.22 0.756
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2jdv L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
1rej B1LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
2xj2 985Serine/threonine-protein kinase pim-1 2.7.11.1 0.685
1cgk NARChalcone synthase 2 2.3.1.74 0.682
1m2r MNYCasein kinase II subunit alpha 2.7.11.1 0.673
1rek B8LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4chq CWUIntegrase / 0.668
3q9z TXQCasein kinase II subunit alpha 2.7.11.1 0.667
3oog YTPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.664
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3q3b 55EGlycogen synthase kinase-3 beta 2.7.11.26 0.661
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.661
2i0v 6C3Macrophage colony-stimulating factor 1 receptor 2.7.10.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4btk DTQTau-tubulin kinase 1 2.7.11.1 0.659
2yqu FADDihydrolipoyl dehydrogenase / 0.658
3zze 6XPHepatocyte growth factor receptor 2.7.10.1 0.657
4cgf UJ6Integrase / 0.657
4g3f 0WBMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.657
2cct 2E1Heat shock protein HSP 90-alpha / 0.654
3uix Q17Serine/threonine-protein kinase pim-1 2.7.11.1 0.654
2uwd 2GGHeat shock protein HSP 90-alpha / 0.653
2bt0 CT5Heat shock protein HSP 90-alpha / 0.652
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.651
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.651
3r02 UNMSerine/threonine-protein kinase pim-1 2.7.11.1 0.651
2jds L20cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650