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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3orp AGS Serine/threonine protein kinase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3orp AGSSerine/threonine protein kinase / 1.015
3ort AGSSerine/threonine protein kinase / 0.988
3oro AGSSerine/threonine protein kinase / 0.773
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.764
3ori AGSSerine/threonine protein kinase / 0.762
3a8w ATPProtein kinase C iota type 2.7.11.13 0.750
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.749
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.747
3ork AGSSerine/threonine protein kinase / 0.745
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.735
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.729
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.722
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.721
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.718
3orm AGSSerine/threonine protein kinase / 0.712
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.709
2wqe ADPAurora kinase A 2.7.11.1 0.707
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.706
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.698
4qml ANPSerine/threonine-protein kinase 24 2.7.11.1 0.697
3nie ANPMitogen-activated protein kinase / 0.696
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.693
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.693
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.690
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.690
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.687
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.685
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.684
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.681
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.680
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.680
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.679
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.675
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.675
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.674
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.672
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.672
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.671
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.671
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.670
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.670
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.670
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.668
4jrn ANPRhoptry kinase family protein / 0.668
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.667
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.666
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.664
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.663
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.663
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.663
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.661
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.661
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.660
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.659
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
2pyw ADPMethylthioribose kinase 2.7.1.100 0.658
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.658
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.656
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.655
2dwb ANPAurora kinase A 2.7.11.1 0.654
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.654
1u54 ACPActivated CDC42 kinase 1 / 0.653
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.653
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.652
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.651
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.651
4xlv ACPInsulin receptor 2.7.10.1 0.651
5l8l ADPAurora kinase A 2.7.11.1 0.651
2pup ADPMethylthioribose kinase 2.7.1.100 0.650
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650