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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nxx NDP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nxx NDPDihydrofolate reductase 1.5.1.3 1.310
2w3b NDPDihydrofolate reductase 1.5.1.3 1.175
8dfr NDPDihydrofolate reductase 1.5.1.3 1.118
1dr5 NAPDihydrofolate reductase 1.5.1.3 1.051
1dr3 TAPDihydrofolate reductase 1.5.1.3 1.018
1dr2 TAPDihydrofolate reductase 1.5.1.3 1.005
3d84 NDPDihydrofolate reductase 1.5.1.3 0.942
4m6j NDPDihydrofolate reductase 1.5.1.3 0.930
3tqa NDPDihydrofolate reductase / 0.923
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.908
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.863
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.862
5ecc NAPDehydrofolate reductase type I / 0.850
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.848
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.838
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.814
1m78 NDPDihydrofolate reductase 1.5.1.3 0.793
2cig 1DGDihydrofolate reductase 1.5.1.3 0.779
1ia1 NDPDihydrofolate reductase 1.5.1.3 0.774
1ra3 NAPDihydrofolate reductase 1.5.1.3 0.766
4xt5 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.765
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.758
3hbb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.733
1j3j NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.719
1drh NAPDihydrofolate reductase 1.5.1.3 0.717
1juv NDPDihydrofolate reductase 1.5.1.3 0.716
2xw7 NDPDihydrofolate reductase / 0.711
4xt6 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.708
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.707
1rx8 NAPDihydrofolate reductase 1.5.1.3 0.688
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.685
2azn NAP2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase / 0.673
4xt4 NAPPossible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc / 0.669
3qlr NDPDihydrofolate reductase 1.5.1.3 0.667
2d5n NDPRiboflavin biosynthesis protein RibD 1.1.1.193 0.659
5a03 NDPGlucose-fructose oxidoreductase / 0.656