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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nx4 NAP Putative oxidoreductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nx4 NAPPutative oxidoreductase / 1.296
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.910
1yqx NAPSinapyl alcohol dehydrogenase / 0.750
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.746
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.734
3tqh NDPQuinone oxidoreductase / 0.732
1yqd NAPSinapyl alcohol dehydrogenase / 0.719
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.705
4plp NADHomospermidine synthase 2.5.1.44 0.704
4xq9 NADHomospermidine synthase 2.5.1.44 0.704
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.701
4xqc NADHomospermidine synthase 2.5.1.44 0.700
5doz NDPJamJ / 0.697
4y0k NAPAntE / 0.696
2y05 NAPProstaglandin reductase 1 / 0.694
4oaq NDPR-specific carbonyl reductase / 0.691
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.689
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.689
4xrg NADHomospermidine synthase 2.5.1.44 0.685
3wbf NAPMeso-diaminopimelate D-dehydrogenase / 0.683
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.683
2o4c NADErythronate-4-phosphate dehydrogenase / 0.682
1u7h NADPutative ornithine cyclodeaminase / 0.680
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.680
2vwh NAPGlucose 1-dehydrogenase / 0.675
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.674
1llu NADAlcohol dehydrogenase / 0.674
3wle NAD(R)-specific carbonyl reductase / 0.674
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.673
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.672
1ur5 NADMalate dehydrogenase / 0.671
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.669
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.669
1uxj NADMalate dehydrogenase / 0.667
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.667
4rqu NADAlcohol dehydrogenase class-P / 0.667
5a06 NDPGlucose-fructose oxidoreductase / 0.666
1pjc NADAlanine dehydrogenase / 0.665
4tvb NADHomospermidine synthase 2.5.1.44 0.665
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.664
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.664
3kb6 NADD-lactate dehydrogenase / 0.663
4b7x NAPProbable oxidoreductase / 0.661
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.661
4y1b NAPAntE / 0.660
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.660
2vwq NAPGlucose 1-dehydrogenase / 0.659
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.659
4xb2 NDP319aa long hypothetical homoserine dehydrogenase / 0.659
1uxk NADMalate dehydrogenase / 0.658
3wyc NAPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.657
5a03 NDPGlucose-fructose oxidoreductase / 0.655
1pzg A3DLactate dehydrogenase / 0.653
1vc2 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.653
1x7d NADPutative ornithine cyclodeaminase / 0.653
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.653
1guy NADMalate dehydrogenase / 0.652
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.651
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.651
1pzh NADLactate dehydrogenase / 0.651
2x0i NAIMalate dehydrogenase / 0.650
3jyn NDPQuinone oxidoreductase / 0.650