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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nhx ASD Steroid Delta-isomerase 5.3.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nhx ASDSteroid Delta-isomerase 5.3.3.1 1.001
3nbr ASDSteroid Delta-isomerase 5.3.3.1 0.906
3nuv ASDSteroid Delta-isomerase 5.3.3.1 0.823
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
5dx3 ESTEstrogen receptor / 0.719
3s79 ASDAromatase 1.14.14.14 0.715
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.714
5hyr ESTEstrogen receptor / 0.712
2pio DHTAndrogen receptor / 0.701
4q0a 4OAVitamin D3 receptor A / 0.700
1e3r ANDSteroid Delta-isomerase 5.3.3.1 0.695
2pit DHTAndrogen receptor / 0.694
4ofu DHTAndrogen receptor / 0.693
2piw DHTAndrogen receptor / 0.692
4pxm ESTEstrogen receptor / 0.691
1t5z DHTAndrogen receptor / 0.685
3w5q 3KLVitamin D3 receptor / 0.685
3m8c EQUSteroid Delta-isomerase 5.3.3.1 0.684
1w6y EQUSteroid Delta-isomerase 5.3.3.1 0.683
2piv DHTAndrogen receptor / 0.683
2q7i TESAndrogen receptor / 0.683
1t74 DHTAndrogen receptor / 0.682
2piu DHTAndrogen receptor / 0.681
3q95 ESLEstrogen receptor / 0.680
1t7r DHTAndrogen receptor / 0.679
4oed DHTAndrogen receptor / 0.679
2ama DHTAndrogen receptor / 0.677
2pir DHTAndrogen receptor / 0.677
2w8y 486Progesterone receptor / 0.675
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.674
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.669
4oea DHTAndrogen receptor / 0.669
1t65 DHTAndrogen receptor / 0.667
4oey DHTAndrogen receptor / 0.666
1t76 DHTAndrogen receptor / 0.665
3ov4 EQUSteroid Delta-isomerase 5.3.3.1 0.665
4ofr DHTAndrogen receptor / 0.665
1t7f DHTAndrogen receptor / 0.664
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1t7t DHTAndrogen receptor / 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1kdk DHTSex hormone-binding globulin / 0.659
2pix DHTAndrogen receptor / 0.659
1f5f DHTSex hormone-binding globulin / 0.656
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.654
1lhu ESTSex hormone-binding globulin / 0.653
2piq DHTAndrogen receptor / 0.653
1q13 TESProstaglandin-E(2) 9-reductase 1.1.1.189 0.650