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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3nbr ASD Steroid Delta-isomerase 5.3.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3nbr ASDSteroid Delta-isomerase 5.3.3.1 1.034
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.906
3nuv ASDSteroid Delta-isomerase 5.3.3.1 0.821
5dx3 ESTEstrogen receptor / 0.699
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.690
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.672
4ofr DHTAndrogen receptor / 0.670
3s79 ASDAromatase 1.14.14.14 0.669
1e3r ANDSteroid Delta-isomerase 5.3.3.1 0.668
2piu DHTAndrogen receptor / 0.666
1zq5 E04Aldo-keto reductase family 1 member C3 / 0.663
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.663
2z1x PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.662
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.662
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.662
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.661
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.661
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2puc GUNHTH-type transcriptional repressor PurR / 0.660
4e5l DBHPolymerase acidic protein / 0.660
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.660
2piq DHTAndrogen receptor / 0.659
2pir DHTAndrogen receptor / 0.659
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.659
1l2i ETCEstrogen receptor / 0.658
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.658
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.658
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.656
1t63 DHTAndrogen receptor / 0.655
4e5f 0N7Polymerase acidic protein / 0.655
1coy ANDCholesterol oxidase 1.1.3.6 0.654
2pkl DHTAndrogen receptor / 0.653
4oez DHTAndrogen receptor / 0.652
2piv DHTAndrogen receptor / 0.651
1q13 TESProstaglandin-E(2) 9-reductase 1.1.1.189 0.650
1y5r C0RCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.650
3oll ESTEstrogen receptor beta / 0.650
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.650