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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3mc5 393 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3mc5 393Aldose reductase 1.1.1.21 1.055
3m64 393Aldose reductase 1.1.1.21 0.995
2pzn 393Aldose reductase 1.1.1.21 0.994
2pdp 393Aldose reductase 1.1.1.21 0.979
2ikj 393Aldose reductase 1.1.1.21 0.958
2pdc 393Aldose reductase 1.1.1.21 0.926
2pdj 393Aldose reductase 1.1.1.21 0.923
2pdu 393Aldose reductase 1.1.1.21 0.875
3t42 3T4Aldose reductase 1.1.1.21 0.838
3lql LDTAldose reductase 1.1.1.21 0.836
3ghr LDTAldose reductase 1.1.1.21 0.816
3ghs LDTAldose reductase 1.1.1.21 0.811
3ght LDTAldose reductase 1.1.1.21 0.801
3ghu LDTAldose reductase 1.1.1.21 0.801
3ld5 LDTAldose reductase 1.1.1.21 0.801
3lz5 LDTAldose reductase 1.1.1.21 0.797
2iki 388Aldose reductase 1.1.1.21 0.796
3lbo LDTAldose reductase 1.1.1.21 0.791
3m4h 388Aldose reductase 1.1.1.21 0.791
2qxw LDTAldose reductase 1.1.1.21 0.778
2i17 LDTAldose reductase 1.1.1.21 0.763
1us0 LDTAldose reductase 1.1.1.21 0.759
2i16 LDTAldose reductase 1.1.1.21 0.759
2duz ZSTAldose reductase 1.1.1.21 0.756
2hv5 ZSTAldose reductase 1.1.1.21 0.756
2pdf ZSTAldose reductase 1.1.1.21 0.740
1t40 ID5Aldose reductase 1.1.1.21 0.737
2dv0 ZSTAldose reductase 1.1.1.21 0.735
4yu1 53NAldose reductase 1.1.1.21 0.735
2dux ZSTAldose reductase 1.1.1.21 0.716
3g5e Q74Aldose reductase 1.1.1.21 0.714
1z3n 3NAAldose reductase 1.1.1.21 0.712
2pdm ZSTAldose reductase 1.1.1.21 0.712
2pd5 ZSTAldose reductase 1.1.1.21 0.711
2hvo ZSTAldose reductase 1.1.1.21 0.710
2fz9 ZSTAldose reductase 1.1.1.21 0.698
2hvn ZSTAldose reductase 1.1.1.21 0.698
2pdb ZSTAldose reductase 1.1.1.21 0.697
2pdn 47DAldose reductase 1.1.1.21 0.695
1iei ZESAldose reductase 1.1.1.21 0.693
2inz OHPAldose reductase 1.1.1.21 0.693
2pdg 47DAldose reductase 1.1.1.21 0.691
3len ZSTAldose reductase 1.1.1.21 0.682
2pdx ZSTAldose reductase 1.1.1.21 0.679
3m0i ZSTAldose reductase 1.1.1.21 0.679
1z89 62PAldose reductase 1.1.1.21 0.675
2ikh LITAldose reductase 1.1.1.21 0.675
2nvc ITAAldose reductase 1.1.1.21 0.672
2pdq 47DAldose reductase 1.1.1.21 0.671
3s3g TLTAldose reductase 1.1.1.21 0.666
2fz8 ZSTAldose reductase 1.1.1.21 0.662
2pdl TOLAldose reductase 1.1.1.21 0.661
2pdh 47DAldose reductase 1.1.1.21 0.660
2pdi ZSTAldose reductase 1.1.1.21 0.656