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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3m64 393 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3m64 393Aldose reductase 1.1.1.21 1.055
2ikj 393Aldose reductase 1.1.1.21 1.033
3mc5 393Aldose reductase 1.1.1.21 0.995
2pzn 393Aldose reductase 1.1.1.21 0.992
2pdc 393Aldose reductase 1.1.1.21 0.991
2pdj 393Aldose reductase 1.1.1.21 0.962
2pdp 393Aldose reductase 1.1.1.21 0.903
3ld5 LDTAldose reductase 1.1.1.21 0.884
3t42 3T4Aldose reductase 1.1.1.21 0.878
3lz5 LDTAldose reductase 1.1.1.21 0.872
3lbo LDTAldose reductase 1.1.1.21 0.870
3lql LDTAldose reductase 1.1.1.21 0.856
3ghr LDTAldose reductase 1.1.1.21 0.854
3ghs LDTAldose reductase 1.1.1.21 0.854
3ght LDTAldose reductase 1.1.1.21 0.851
3m4h 388Aldose reductase 1.1.1.21 0.849
2pdu 393Aldose reductase 1.1.1.21 0.848
3ghu LDTAldose reductase 1.1.1.21 0.826
2iki 388Aldose reductase 1.1.1.21 0.821
2qxw LDTAldose reductase 1.1.1.21 0.797
1us0 LDTAldose reductase 1.1.1.21 0.793
2i16 LDTAldose reductase 1.1.1.21 0.793
2i17 LDTAldose reductase 1.1.1.21 0.793
4yu1 53NAldose reductase 1.1.1.21 0.763
3m0i ZSTAldose reductase 1.1.1.21 0.754
1t40 ID5Aldose reductase 1.1.1.21 0.747
2fz9 ZSTAldose reductase 1.1.1.21 0.744
2pd5 ZSTAldose reductase 1.1.1.21 0.734
2hv5 ZSTAldose reductase 1.1.1.21 0.728
2pdb ZSTAldose reductase 1.1.1.21 0.726
2duz ZSTAldose reductase 1.1.1.21 0.714
2hvn ZSTAldose reductase 1.1.1.21 0.714
2dux ZSTAldose reductase 1.1.1.21 0.713
1z3n 3NAAldose reductase 1.1.1.21 0.710
2pdm ZSTAldose reductase 1.1.1.21 0.710
2inz OHPAldose reductase 1.1.1.21 0.708
3g5e Q74Aldose reductase 1.1.1.21 0.707
2is7 2CLAldose reductase 1.1.1.21 0.706
3s3g TLTAldose reductase 1.1.1.21 0.703
2dv0 ZSTAldose reductase 1.1.1.21 0.698
2fz8 ZSTAldose reductase 1.1.1.21 0.697
3len ZSTAldose reductase 1.1.1.21 0.696
2pdx ZSTAldose reductase 1.1.1.21 0.694
2pdh 47DAldose reductase 1.1.1.21 0.693
2ikh LITAldose reductase 1.1.1.21 0.692
1t41 ID5Aldose reductase 1.1.1.21 0.691
2pdf ZSTAldose reductase 1.1.1.21 0.691
3u2c SUZAldose reductase 1.1.1.21 0.688
1frb ZSTAldose reductase-related protein 2 / 0.680
1z89 62PAldose reductase 1.1.1.21 0.680
1iei ZESAldose reductase 1.1.1.21 0.676
2nvc ITAAldose reductase 1.1.1.21 0.675
2pdi ZSTAldose reductase 1.1.1.21 0.675
1zua TOLAldo-keto reductase family 1 member B10 1.1.1 0.673
2fzb TOLAldose reductase 1.1.1.21 0.669
2fzd TOLAldose reductase 1.1.1.21 0.667
2pdl TOLAldose reductase 1.1.1.21 0.667
2pdq 47DAldose reductase 1.1.1.21 0.666
3mb9 ZSTAldose reductase 1.1.1.21 0.665
2pdn 47DAldose reductase 1.1.1.21 0.662
1pwl BFIAldose reductase 1.1.1.21 0.657