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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3lfq A28 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 1.008
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.923
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.780
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.770
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.768
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.748
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.741
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.740
3igg EFQCyclin-dependent kinase 2 2.7.11.22 0.738
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.737
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.725
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.723
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.719
4ag8 AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.711
2vtq LZACyclin-dependent kinase 2 2.7.11.22 0.706
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.705
3ql8 X01Cyclin-dependent kinase 2 2.7.11.22 0.700
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.694
2r3l SCWCyclin-dependent kinase 2 2.7.11.22 0.692
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.692
2vto LZ8Cyclin-dependent kinase 2 2.7.11.22 0.688
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.687
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.685
4f64 0S8Fibroblast growth factor receptor 1 / 0.685
1dm2 HMDCyclin-dependent kinase 2 2.7.11.22 0.684
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.683
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.683
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.682
4f63 0S7Fibroblast growth factor receptor 1 / 0.681
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.680
4lyn 1YGCyclin-dependent kinase 2 2.7.11.22 0.679
2bhe BRYCyclin-dependent kinase 2 2.7.11.22 0.678
2r3g SC9Cyclin-dependent kinase 2 2.7.11.22 0.678
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.677
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.676
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.674
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.674
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.674
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.672
3ggf GVDSerine/threonine-protein kinase 26 / 0.672
3fz1 B98Cyclin-dependent kinase 2 2.7.11.22 0.670
3qqg X06Cyclin-dependent kinase 2 2.7.11.22 0.667
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.665
3w16 P9JAurora kinase A 2.7.11.1 0.665
1pxo CK7Cyclin-dependent kinase 2 2.7.11.22 0.664
3sqq 99ZCyclin-dependent kinase 2 2.7.11.22 0.662
2c3l IDZSerine/threonine-protein kinase Chk1 2.7.11.1 0.661
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.661
3zdu 38RCyclin-dependent kinase-like 3 2.7.11.22 0.658
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.658
2r3m SCXCyclin-dependent kinase 2 2.7.11.22 0.657
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.657
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.654
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.654
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.654
2j4z 626Aurora kinase A 2.7.11.1 0.653
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.652
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.650