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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hv7 1AU Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3hv7 1AUMitogen-activated protein kinase 14 / 1.217
2yiw YIWMitogen-activated protein kinase 14 / 0.983
2yis YISMitogen-activated protein kinase 14 / 0.952
3p7b P7BMitogen-activated protein kinase 14 / 0.914
3nnx EDDMitogen-activated protein kinase 14 / 0.911
1kv2 B96Mitogen-activated protein kinase 14 / 0.900
2puu G2GMitogen-activated protein kinase 14 / 0.896
3p5k P5KMitogen-activated protein kinase 14 / 0.889
3hv6 R39Mitogen-activated protein kinase 14 / 0.886
3nnw EDDMitogen-activated protein kinase 14 / 0.871
3uvr 06FMitogen-activated protein kinase 14 / 0.863
3gcq 1BUMitogen-activated protein kinase 14 / 0.834
3p7c P7CMitogen-activated protein kinase 14 / 0.833
3nnu EDBMitogen-activated protein kinase 14 / 0.829
3lfe Z84Mitogen-activated protein kinase 14 / 0.828
1w82 L10Mitogen-activated protein kinase 14 / 0.818
3hv3 R49Mitogen-activated protein kinase 14 / 0.818
3gi3 B10Mitogen-activated protein kinase 14 / 0.808
3p7a P7AMitogen-activated protein kinase 14 / 0.798
3hv5 R24Mitogen-activated protein kinase 14 / 0.796
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.788
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.764
3hv4 L51Mitogen-activated protein kinase 14 / 0.763
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.763
3lff Z83Mitogen-activated protein kinase 14 / 0.761
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.740
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.733
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.725
3gcv SS6Mitogen-activated protein kinase 14 / 0.718
3p79 P79Mitogen-activated protein kinase 14 / 0.715
3o8t BMUMitogen-activated protein kinase 14 / 0.712
3o8u BMUMitogen-activated protein kinase 14 / 0.710
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.708
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.706
4twn B96Ephrin type-A receptor 3 2.7.10.1 0.702
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.692
3gcu R48Mitogen-activated protein kinase 14 / 0.691
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.690
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.683
4k9y K9YFocal adhesion kinase 1 2.7.10.2 0.681
3oc1 BMUMitogen-activated protein kinase 14 / 0.678
3k3j F4CMitogen-activated protein kinase 14 / 0.677
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.677
3uvq FS8Mitogen-activated protein kinase 14 / 0.668
1wbn L09Mitogen-activated protein kinase 14 / 0.664
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.663
1wbv LI3Mitogen-activated protein kinase 14 / 0.661
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.661
3bv2 P38Mitogen-activated protein kinase 14 / 0.660
3p78 P78Mitogen-activated protein kinase 14 / 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.655
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.655
1nb9 RBFRiboflavin kinase 2.7.1.26 0.652