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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3hbb NAP Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3hbb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 1.054
3kjs NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.789
3clb NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.787
3d84 NDPDihydrofolate reductase 1.5.1.3 0.749
3inv NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.740
3nxx NDPDihydrofolate reductase 1.5.1.3 0.733
2h2q NAPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.724
2w3b NDPDihydrofolate reductase 1.5.1.3 0.719
8dfr NDPDihydrofolate reductase 1.5.1.3 0.714
3tqa NDPDihydrofolate reductase / 0.711
4kl9 NDPDihydrofolate reductase 1.5.1.3 0.691
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.690
4m6j NDPDihydrofolate reductase 1.5.1.3 0.688
5ecc NAPDehydrofolate reductase type I / 0.682
1ai9 NDPDihydrofolate reductase 1.5.1.3 0.681
1dg8 NDPDihydrofolate reductase 1.5.1.3 0.676
1rx1 NAPDihydrofolate reductase 1.5.1.3 0.667
3dga NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.665
2cig 1DGDihydrofolate reductase 1.5.1.3 0.664
1j3k NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.659
3dg8 NDPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.659