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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3h4g FID Alcohol dehydrogenase [NADP(+)] 1.1.1.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3h4g FIDAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.812
2agt FIDAldose reductase 1.1.1.21 0.755
4e5i 0N9Polymerase acidic protein / 0.744
4ga8 SBIAldo-keto reductase family 1 member B10 1.1.1 0.732
4gab FIDAldo-keto reductase family 1 member B10 1.1.1 0.731
1pwm FIDAldose reductase 1.1.1.21 0.711
2pdw FIDAldose reductase 1.1.1.21 0.707
1ef3 FIDAldose reductase 1.1.1.21 0.704
2pdy FIDAldose reductase 1.1.1.21 0.701
2pdk SBIAldose reductase 1.1.1.21 0.696
1ah0 SBIAldose reductase 1.1.1.21 0.695
2pd9 FIDAldose reductase 1.1.1.21 0.689
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.665
4e5f 0N7Polymerase acidic protein / 0.660
1pwl BFIAldose reductase 1.1.1.21 0.651