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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gye FMN Dihydroorotate dehydrogenase (fumarate)

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gye FMNDihydroorotate dehydrogenase (fumarate) / 1.129
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 1.101
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 1.101
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 1.100
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 1.066
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.052
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.051
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.031
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 1.016
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.967
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.961
3oix FMNDihydroorotate dehydrogenase / 0.880
3tjl FMNNADPH dehydrogenase / 0.846
4df2 FMNNADPH dehydrogenase / 0.836
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.830
3p74 FMNPentaerythritol tetranitrate reductase / 0.812
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.806
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.805
2abb FMNPentaerythritol tetranitrate reductase / 0.804
4tmb FMNOld yellow enzyme / 0.801
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.796
1h63 FMNPentaerythritol tetranitrate reductase / 0.792
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.791
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.790
1h51 FMNPentaerythritol tetranitrate reductase / 0.788
3f03 FMNPentaerythritol tetranitrate reductase / 0.787
4qai FMNNADPH dehydrogenase / 0.787
3p62 FMNPentaerythritol tetranitrate reductase / 0.785
3p84 FMNPentaerythritol tetranitrate reductase / 0.782
4e2d FMNDehydrogenase / 0.780
3p8j FMNPentaerythritol tetranitrate reductase / 0.778
3p67 FMNPentaerythritol tetranitrate reductase / 0.775
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 0.774
2zfa FMNLactate oxidase / 0.770
1vyr FMNPentaerythritol tetranitrate reductase / 0.769
1h50 FMNPentaerythritol tetranitrate reductase / 0.767
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.763
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.761
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.758
3p82 FMNPentaerythritol tetranitrate reductase / 0.757
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.756
2z6i FMN2-nitropropane dioxygenase / 0.756
4e2b FMNDehydrogenase / 0.755
3p8i FMNPentaerythritol tetranitrate reductase / 0.753
4jic FMNGTN Reductase / 0.752
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.751
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.749
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.747
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.747
3aty FMNProstaglandin F2a synthase / 0.744
5ebu FMNLactate oxidase / 0.743
2du2 FMNLactate oxidase / 0.739
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.736
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.733
1gwj FMNMorphinone reductase / 0.733
3gka FMNN-ethylmaleimide reductase / 0.733
2nli FMNLactate oxidase / 0.728
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.727
4utk FNRXenobiotic reductase / 0.723
4yl2 FMNLactate oxidase / 0.723
4m5p FMNNADPH dehydrogenase / 0.721
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.721
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.719
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.717
1llw FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.716
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.716
3gr8 FMNNADPH dehydrogenase / 0.715
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.708
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.704
4tmc FMNOld yellow enzyme / 0.704
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.704
4utl FNRXenobiotic reductase / 0.703
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.701
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.700
3l67 FMNXenobiotic reductase / 0.700
4rje FNRLactate oxidase / 0.699
3atz FMNProstaglandin F2a synthase / 0.697
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.696
4uth FMNXenobiotic reductase / 0.696
4utm FNRXenobiotic reductase / 0.696
3n3b FMNProtein NrdI / 0.694
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.691
5cpm FNRNADH:flavin oxidoreductase / 0.691
2e77 FMNLactate oxidase / 0.690
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.689
2j6x FMNLactate oxidase / 0.684
4yco FMNtRNA-dihydrouridine(16) synthase / 0.683
2h8x FMNXenA / 0.680
3l5l FMNXenobiotic reductase / 0.680
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.678
3w77 FMNFMN-dependent NADH-azoreductase / 0.678
3qe2 FMNNADPH--cytochrome P450 reductase / 0.672
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.670
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.666
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.665
1k8y 13PTryptophan synthase alpha chain / 0.662
1f8r FADL-amino-acid oxidase 1.4.3.2 0.659
1t0i FMNNAD(P)H-dependent FMN reductase LOT6 / 0.659
1qx4 FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.658
3n3a FMNProtein NrdI / 0.657
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.656
4q4k FMNUncharacterized protein / 0.655
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.654
3n39 FMNProtein NrdI / 0.653
4yx6 FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.653
2fzm FADBifunctional protein PutA 1.5.5.2 0.652
2gjl FMNNitronate monooxygenase 1.13.12.16 0.652
4j33 FADKynurenine 3-monooxygenase / 0.652
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.652
1s4m LUMRiboflavin biosynthesis protein / 0.650
2bf4 FMNNADPH--cytochrome P450 reductase / 0.650
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.650
4hj3 FMNLOV protein / 0.650