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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cbl STU Tyrosine-protein kinase Fes/Fps 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 1.091
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 1.064
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 1.023
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.892
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.888
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.868
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.852
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.846
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.845
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.837
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.823
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.808
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.805
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.802
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.780
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.771
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.769
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.768
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.764
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.756
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.751
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.736
1byg STUTyrosine-protein kinase CSK / 0.734
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.731
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.727
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.719
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.719
3zew STUEphrin type-B receptor 4 2.7.10.1 0.718
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.716
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.715
3cqe P91Wee1-like protein kinase 2.7.10.2 0.708
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.698
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.698
1x8b 824Wee1-like protein kinase 2.7.10.2 0.697
1xjd STUProtein kinase C theta type 2.7.11.13 0.695
3cr0 809Wee1-like protein kinase 2.7.10.2 0.683
1wvx BD4Death-associated protein kinase 1 2.7.11.1 0.674
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.665
3biz 61EWee1-like protein kinase 2.7.10.2 0.662
4e5f 0N7Polymerase acidic protein / 0.660
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3qzh X69Cyclin-dependent kinase 2 2.7.11.22 0.653