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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ac1 KZI Tyrosine-protein kinase Lck 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ac1 KZITyrosine-protein kinase Lck 2.7.10.2 0.795
4e5i 0N9Polymerase acidic protein / 0.744
3ac2 KSETyrosine-protein kinase Lck 2.7.10.2 0.717
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.682
4ftc H6KSerine/threonine-protein kinase Chk1 2.7.11.1 0.682
4mv4 ACPBiotin carboxylase 6.3.4.14 0.676
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.669
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.668
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.663
4e5f 0N7Polymerase acidic protein / 0.660
4gva ADPMitogen-activated protein kinase 1 2.7.11.24 0.660
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.655
4dt8 ADNAPH(2'')-Id / 0.655
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.653
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.652
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.651