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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3a4o STU Tyrosine-protein kinase Lyn 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 1.023
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.786
1byg STUTyrosine-protein kinase CSK / 0.754
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.754
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.753
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.733
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.732
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.726
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.724
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.722
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.716
3zew STUEphrin type-B receptor 4 2.7.10.1 0.713
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.706
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.700
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.700
1xjd STUProtein kinase C theta type 2.7.11.13 0.696
2in6 839Wee1-like protein kinase 2.7.10.2 0.691
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.680
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.678
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.677
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.675
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.669
4bid IE8Mitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.666
4e5f 0N7Polymerase acidic protein / 0.660
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.660
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.659
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.656
1wvy STUDeath-associated protein kinase 1 2.7.11.1 0.652
4cd0 AWJALK tyrosine kinase receptor 2.7.10.1 0.652