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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zhq 27U Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zhq 27UProthrombin 3.4.21.5 1.069
2zda 32UProthrombin 3.4.21.5 1.004
2zi2 24UProthrombin 3.4.21.5 0.956
2zg0 50UProthrombin 3.4.21.5 0.950
2znk 31UProthrombin 3.4.21.5 0.949
2zfq 45UProthrombin 3.4.21.5 0.945
2zhf 49UProthrombin 3.4.21.5 0.934
2ziq 26UProthrombin 3.4.21.5 0.928
3utu 1TSProthrombin 3.4.21.5 0.927
4bah MELProthrombin 3.4.21.5 0.918
4ban M6SProthrombin 3.4.21.5 0.916
1ypl RA8Prothrombin 3.4.21.5 0.906
1riw OSCProthrombin 3.4.21.5 0.905
2zgx 29UProthrombin 3.4.21.5 0.903
1k22 MELProthrombin 3.4.21.5 0.902
4bam MM9Prothrombin 3.4.21.5 0.902
4bao MVFProthrombin 3.4.21.5 0.901
2zfr 46UProthrombin 3.4.21.5 0.892
4baq M4ZProthrombin 3.4.21.5 0.882
2anm CDOProthrombin 3.4.21.5 0.881
1ypm RA4Prothrombin 3.4.21.5 0.847
3biv 11UProthrombin 3.4.21.5 0.846
3biu 10UProthrombin 3.4.21.5 0.841
2zdv 37UProthrombin 3.4.21.5 0.840
3qwc 98PProthrombin 3.4.21.5 0.838
2a2x NA9Prothrombin 3.4.21.5 0.837
3p17 99PProthrombin 3.4.21.5 0.835
1c4v IH2Prothrombin 3.4.21.5 0.829
1ae8 AZLProthrombin 3.4.21.5 0.825
2zf0 51UProthrombin 3.4.21.5 0.818
2v3h I25Prothrombin 3.4.21.5 0.810
4bak M67Prothrombin 3.4.21.5 0.802
2zff 53UProthrombin 3.4.21.5 0.788
1ype UIPProthrombin 3.4.21.5 0.782
1k21 IGNProthrombin 3.4.21.5 0.776
2zc9 22UProthrombin 3.4.21.5 0.770
1lpk CBBCoagulation factor X 3.4.21.6 0.768
1ypk CCRProthrombin 3.4.21.5 0.766
3dhk 23UProthrombin 3.4.21.5 0.762
1ypg UIRProthrombin 3.4.21.5 0.759
2cf9 348Prothrombin 3.4.21.5 0.758
2cf8 ESHProthrombin 3.4.21.5 0.757
3qto 10PProthrombin 3.4.21.5 0.757
2cn0 F25Prothrombin 3.4.21.5 0.754
2gde SN3Prothrombin 3.4.21.5 0.750
1wtg 3BPCoagulation factor VII 3.4.21.21 0.748
1ypj UIBProthrombin 3.4.21.5 0.748
1nt1 T76Prothrombin 3.4.21.5 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
3hat GLY_VAL_ARG_RNGProthrombin 3.4.21.5 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3qtv 06PProthrombin 3.4.21.5 0.742
1vja 7INUrokinase-type plasminogen activator 3.4.21.73 0.738
1wqv PSMCoagulation factor VII 3.4.21.21 0.737
5cmx 0G6Prothrombin 3.4.21.5 0.737
1c4u IH1Prothrombin 3.4.21.5 0.731
1c5n ESIProthrombin 3.4.21.5 0.730
1o0d 163Prothrombin 3.4.21.5 0.725
1ta2 176Prothrombin 3.4.21.5 0.718
1ta6 177Prothrombin 3.4.21.5 0.716
1nzq 162Prothrombin 3.4.21.5 0.714
1d4p BPPProthrombin 3.4.21.5 0.709
7kme ACE_0BN_CHG_PRRProthrombin 3.4.21.5 0.709
4ax9 N5NProthrombin 3.4.21.5 0.706
2zhe 13UProthrombin 3.4.21.5 0.703
2pks G44Prothrombin 3.4.21.5 0.702
3eq0 2TSProthrombin 3.4.21.5 0.700
1jwt BLIProthrombin 3.4.21.5 0.697
3dux 64UProthrombin 3.4.21.5 0.697
1wv7 5PICoagulation factor VII 3.4.21.21 0.693
1uvs I11Prothrombin 3.4.21.5 0.691
2c4f GILCoagulation factor VII 3.4.21.21 0.691
2zfp 19UProthrombin 3.4.21.5 0.690
2v3o I26Prothrombin 3.4.21.5 0.688
1lqd CMICoagulation factor X 3.4.21.6 0.687
1zrb 062Prothrombin 3.4.21.5 0.686
1afe ALZProthrombin 3.4.21.5 0.683
1nm6 L86Prothrombin 3.4.21.5 0.683
2zhw 12UProthrombin 3.4.21.5 0.682
1kts C24Prothrombin 3.4.21.5 0.681
1owe 675Urokinase-type plasminogen activator 3.4.21.73 0.681
1d9i 00PProthrombin 3.4.21.5 0.680
1owk 303Urokinase-type plasminogen activator 3.4.21.73 0.679
1sl3 170Prothrombin 3.4.21.5 0.679
1mue CDDProthrombin 3.4.21.5 0.676
3c1k T15Prothrombin 3.4.21.5 0.672
1t4v 14AProthrombin 3.4.21.5 0.670
1gj4 132Prothrombin 3.4.21.5 0.669
1ny2 ARG_PRO_PRO_GLYProthrombin 3.4.21.5 0.666
2bxt C2DProthrombin 3.4.21.5 0.666
3f68 91UProthrombin 3.4.21.5 0.665
4ayv 9MQProthrombin 3.4.21.5 0.665
2zgb 21UProthrombin 3.4.21.5 0.663
1o5g CR9Prothrombin 3.4.21.5 0.662
2zp0 PI0Coagulation factor VII 3.4.21.21 0.662
2zeb 11MTryptase alpha/beta-1 3.4.21.59 0.658
4ayy 9MXProthrombin 3.4.21.5 0.653
3qdz PRO_ALA_PRO_ARGProthrombin 3.4.21.5 0.652