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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zgx 29U Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
2zgx 29UProthrombin 3.4.21.5 1.005
2zi2 24UProthrombin 3.4.21.5 0.942
2zda 32UProthrombin 3.4.21.5 0.940
2zhq 27UProthrombin 3.4.21.5 0.903
2zhf 49UProthrombin 3.4.21.5 0.886
2zg0 50UProthrombin 3.4.21.5 0.885
2zfq 45UProthrombin 3.4.21.5 0.876
2zfr 46UProthrombin 3.4.21.5 0.871
2ziq 26UProthrombin 3.4.21.5 0.850
1riw OSCProthrombin 3.4.21.5 0.841
4ban M6SProthrombin 3.4.21.5 0.831
4bao MVFProthrombin 3.4.21.5 0.831
4bam MM9Prothrombin 3.4.21.5 0.822
2zdv 37UProthrombin 3.4.21.5 0.821
2gde SN3Prothrombin 3.4.21.5 0.819
2znk 31UProthrombin 3.4.21.5 0.818
1ypl RA8Prothrombin 3.4.21.5 0.812
1ypm RA4Prothrombin 3.4.21.5 0.811
1k21 IGNProthrombin 3.4.21.5 0.809
3hat GLY_VAL_ARG_RNGProthrombin 3.4.21.5 0.807
2zhe 13UProthrombin 3.4.21.5 0.805
3qwc 98PProthrombin 3.4.21.5 0.805
3biv 11UProthrombin 3.4.21.5 0.802
2v3h I25Prothrombin 3.4.21.5 0.790
2zff 53UProthrombin 3.4.21.5 0.790
1wtg 3BPCoagulation factor VII 3.4.21.21 0.788
1k22 MELProthrombin 3.4.21.5 0.787
2zf0 51UProthrombin 3.4.21.5 0.785
3p17 99PProthrombin 3.4.21.5 0.776
4baq M4ZProthrombin 3.4.21.5 0.769
2zc9 22UProthrombin 3.4.21.5 0.768
1c4u IH1Prothrombin 3.4.21.5 0.765
1ypk CCRProthrombin 3.4.21.5 0.765
1c4v IH2Prothrombin 3.4.21.5 0.761
1ae8 AZLProthrombin 3.4.21.5 0.757
4ayy 9MXProthrombin 3.4.21.5 0.754
3qto 10PProthrombin 3.4.21.5 0.753
3utu 1TSProthrombin 3.4.21.5 0.750
4bak M67Prothrombin 3.4.21.5 0.749
1ype UIPProthrombin 3.4.21.5 0.747
2cn0 F25Prothrombin 3.4.21.5 0.747
3dhk 23UProthrombin 3.4.21.5 0.747
3qtv 06PProthrombin 3.4.21.5 0.746
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1lpk CBBCoagulation factor X 3.4.21.6 0.744
2zfp 19UProthrombin 3.4.21.5 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4bah MELProthrombin 3.4.21.5 0.743
3eq0 2TSProthrombin 3.4.21.5 0.742
4e7r 0NWProthrombin 3.4.21.5 0.742
1d4p BPPProthrombin 3.4.21.5 0.741
2cf9 348Prothrombin 3.4.21.5 0.739
3biu 10UProthrombin 3.4.21.5 0.739
4ayv 9MQProthrombin 3.4.21.5 0.736
1wqv PSMCoagulation factor VII 3.4.21.21 0.734
1ypg UIRProthrombin 3.4.21.5 0.730
2anm CDOProthrombin 3.4.21.5 0.730
4ax9 N5NProthrombin 3.4.21.5 0.728
1c5n ESIProthrombin 3.4.21.5 0.720
1o0d 163Prothrombin 3.4.21.5 0.720
3plp BBACationic trypsin 3.4.21.4 0.720
1ta2 176Prothrombin 3.4.21.5 0.719
1zsk 421Coagulation factor XI 3.4.21.27 0.718
4az2 9MUProthrombin 3.4.21.5 0.715
1nt1 T76Prothrombin 3.4.21.5 0.713
1ta6 177Prothrombin 3.4.21.5 0.713
2cf8 ESHProthrombin 3.4.21.5 0.712
2zp0 PI0Coagulation factor VII 3.4.21.21 0.712
1wv7 5PICoagulation factor VII 3.4.21.21 0.707
1ghv 120Prothrombin 3.4.21.5 0.705
1xm1 GAHProthrombin 3.4.21.5 0.702
1ypj UIBProthrombin 3.4.21.5 0.702
1vja 7INUrokinase-type plasminogen activator 3.4.21.73 0.700
1vzq SHYProthrombin 3.4.21.5 0.688
1c1u BAIProthrombin 3.4.21.5 0.687
2zgb 21UProthrombin 3.4.21.5 0.687
1zrb 062Prothrombin 3.4.21.5 0.686
2a2x NA9Prothrombin 3.4.21.5 0.686
3f68 91UProthrombin 3.4.21.5 0.686
2zhw 12UProthrombin 3.4.21.5 0.684
1d9i 00PProthrombin 3.4.21.5 0.682
2c4f GILCoagulation factor VII 3.4.21.21 0.682
3dux 64UProthrombin 3.4.21.5 0.676
5cmx 0G6Prothrombin 3.4.21.5 0.673
1afe ALZProthrombin 3.4.21.5 0.671
1sl3 170Prothrombin 3.4.21.5 0.670
7kme ACE_0BN_CHG_PRRProthrombin 3.4.21.5 0.669
2pks G44Prothrombin 3.4.21.5 0.667
1o2g 696Prothrombin 3.4.21.5 0.666
3qdz PRO_ALA_PRO_ARGProthrombin 3.4.21.5 0.665
1uvs I11Prothrombin 3.4.21.5 0.664
2bok 784Coagulation factor X 3.4.21.6 0.663
4e5f 0N7Polymerase acidic protein / 0.660
1lqd CMICoagulation factor X 3.4.21.6 0.658
1owi 426Urokinase-type plasminogen activator 3.4.21.73 0.658
4dju 0KKBeta-secretase 1 3.4.23.46 0.650
4jpc 1M6Beta-secretase 1 3.4.23.46 0.650