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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zfa FMN Lactate oxidase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zfa FMNLactate oxidase / 1.366
2nli FMNLactate oxidase / 1.344
4yl2 FMNLactate oxidase / 1.229
2j6x FMNLactate oxidase / 1.222
4rje FNRLactate oxidase / 1.153
2e77 FMNLactate oxidase / 1.117
5ebu FMNLactate oxidase / 1.019
2du2 FMNLactate oxidase / 0.933
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.921
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.901
1fcb FMNCytochrome b2, mitochondrial 1.1.2.3 0.887
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 0.875
3n19 FNRXenobiotic reductase / 0.874
3giy FMN(S)-mandelate dehydrogenase 1.1.99.31 0.868
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.863
3n14 FMNXenobiotic reductase / 0.861
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.859
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.856
4uth FMNXenobiotic reductase / 0.854
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.850
3l67 FMNXenobiotic reductase / 0.846
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 0.837
4utm FNRXenobiotic reductase / 0.832
4jic FMNGTN Reductase / 0.826
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.820
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.819
4tmb FMNOld yellow enzyme / 0.818
3l5l FMNXenobiotic reductase / 0.817
4aws FMNNADH:flavin oxidoreductase Sye1 / 0.817
1z41 FMNNADPH dehydrogenase / 0.810
4e2b FMNDehydrogenase / 0.810
2h8x FMNXenA / 0.807
4e2d FMNDehydrogenase / 0.803
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 0.800
1z44 FMNNADPH dehydrogenase / 0.798
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.797
3aty FMNProstaglandin F2a synthase / 0.797
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.796
3p74 FMNPentaerythritol tetranitrate reductase / 0.793
3f03 FMNPentaerythritol tetranitrate reductase / 0.791
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.791
1z48 FMNNADPH dehydrogenase / 0.788
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.785
1vhn FMNtRNA-dihydrouridine synthase / 0.783
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.781
3atz FMNProstaglandin F2a synthase / 0.780
1szg FNSCytochrome b2, mitochondrial 1.1.2.3 0.772
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.771
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.770
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.770
1h51 FMNPentaerythritol tetranitrate reductase / 0.764
3p84 FMNPentaerythritol tetranitrate reductase / 0.763
1vyr FMNPentaerythritol tetranitrate reductase / 0.762
2oz0 FMNCytochrome b2, mitochondrial 1.1.2.3 0.762
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.751
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.749
4utl FNRXenobiotic reductase / 0.749
3gka FMNN-ethylmaleimide reductase / 0.747
3gr8 FMNNADPH dehydrogenase / 0.747
3p62 FMNPentaerythritol tetranitrate reductase / 0.742
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.741
3p8j FMNPentaerythritol tetranitrate reductase / 0.731
1gwj FMNMorphinone reductase / 0.725
1qcw FNSCytochrome b2, mitochondrial 1.1.2.3 0.721
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.721
2z6i FMN2-nitropropane dioxygenase / 0.716
3hf3 FMNChromate reductase / 0.712
3b04 OOPIsopentenyl-diphosphate delta-isomerase / 0.708
1kyv RBF6,7-dimethyl-8-ribityllumazine synthase 2.5.1.78 0.707
4cw5 FMNDfnA / 0.704
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.701
1siq FADGlutaryl-CoA dehydrogenase, mitochondrial 1.3.8.6 0.698
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.696
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.695
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.692
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.692
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.690
1buc FADAcyl-CoA dehydrogenase, short-chain specific 1.3.8.1 0.689
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.688
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.687
3w8w FADPutative FAD-dependent oxygenase EncM / 0.684
4ttc FMNIodotyrosine deiodinase 1 / 0.683
1amo FMNNADPH--cytochrome P450 reductase / 0.680
4oxx FMNCindoxin / 0.680
1wsb FMNFlavodoxin / 0.677
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.677
2vnj FADNADPH:ferredoxin reductase / 0.673
4tmc FMNOld yellow enzyme / 0.672
1nqv LMZ6,7-dimethyl-8-ribityllumazine synthase 2.5.1.78 0.670
2fcr FMNFlavodoxin / 0.670
2a58 RBF6,7-dimethyl-8-ribityllumazine synthase 2.5.1.78 0.669
1u4s BIHL-lactate dehydrogenase 1.1.1.27 0.668
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.668
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.668
3djl FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.667
3mkh FADNitroalkane oxidase / 0.667
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.665
4qly FMNEnone reductase CLA-ER / 0.664
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.663
3e78 TPPHigh affinity transport system protein p37 / 0.663
3tjl FMNNADPH dehydrogenase / 0.663
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.660
4df4 0L3DNA polymerase I, thermostable 2.7.7.7 0.660
4i6g FADCryptochrome-2 / 0.660
2vyx FMNDodecin / 0.659
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.659
3nf4 FADAcyl-CoA dehydrogenase domain-containing protein / 0.659
4df2 FMNNADPH dehydrogenase / 0.659
4hs4 FMNChromate reductase / 0.659
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.658
3qfr FMNNADPH--cytochrome P450 reductase / 0.658
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.658
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.657
2wq6 FADRE11660p / 0.656
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.656
4hut ATPCob(I)yrinic acid a,c-diamide adenosyltransferase 2.5.1.17 0.656
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.655
2j4d FADCryptochrome DASH, chloroplastic/mitochondrial / 0.655
2pg0 FADAcyl-CoA dehydrogenase / 0.655
2r2n KYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.655
4y7c FMNNADPH--cytochrome P450 reductase / 0.655
1ao0 5GPAmidophosphoribosyltransferase / 0.652
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.652
4typ AP5Adenylate kinase / 0.651
2ohi FMNType A flavoprotein FprA 1 0.650