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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ym7 YM7 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ym7 YM7Serine/threonine-protein kinase Chk1 2.7.11.1 0.882
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.712
2pzr ACPFibroblast growth factor receptor 2 / 0.676
4i5c C5ITyrosine-protein kinase JAK1 / 0.676
2wmw ZYWSerine/threonine-protein kinase Chk1 2.7.11.1 0.675
4e4n 0NLTyrosine-protein kinase JAK1 / 0.664
2wmv ZYVSerine/threonine-protein kinase Chk1 2.7.11.1 0.662
4ftc H6KSerine/threonine-protein kinase Chk1 2.7.11.1 0.662
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.657
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.656
2ym8 YM8Serine/threonine-protein kinase Chk1 2.7.11.1 0.656
2ym4 4YMSerine/threonine-protein kinase Chk1 2.7.11.1 0.655
3lxp IZANon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.650
4oti MI1Serine/threonine-protein kinase N1 / 0.650