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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ym3 YM3 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.899
2wmw ZYWSerine/threonine-protein kinase Chk1 2.7.11.1 0.768
4e5i 0N9Polymerase acidic protein / 0.744
4f08 1RSTyrosine-protein kinase JAK2 / 0.729
2ym4 4YMSerine/threonine-protein kinase Chk1 2.7.11.1 0.722
2ym7 YM7Serine/threonine-protein kinase Chk1 2.7.11.1 0.712
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.694
2ym6 YM6Serine/threonine-protein kinase Chk1 2.7.11.1 0.688
4e6q 0NVTyrosine-protein kinase JAK2 / 0.686
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.685
4ivd 15TTyrosine-protein kinase JAK1 / 0.682
2brb PFQSerine/threonine-protein kinase Chk1 2.7.11.1 0.676
4feq 0T8Tyrosine-protein kinase receptor TYRO3 2.7.10.1 0.673
4f09 JAKTyrosine-protein kinase JAK2 / 0.671
4e5f 0N7Polymerase acidic protein / 0.660
4i5c C5ITyrosine-protein kinase JAK1 / 0.660
2bfy H1NAurora kinase B-A 2.7.11.1 0.658
2wmv ZYVSerine/threonine-protein kinase Chk1 2.7.11.1 0.657
4ft7 H3KSerine/threonine-protein kinase Chk1 2.7.11.1 0.654
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.651
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.651
3b2t M33Fibroblast growth factor receptor 2 / 0.650