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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ye4 2FY Heat shock protein HSP 90-alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ye4 2FYHeat shock protein HSP 90-alpha / 0.888
3eko PYUHeat shock protein HSP 90-alpha / 0.775
2yi6 6QMHeat shock protein HSP 90-alpha / 0.768
4b7p 9UNHeat shock protein HSP 90-alpha / 0.764
2yk2 YJWHeat shock protein HSP 90-alpha / 0.759
2xab VHDHeat shock protein HSP 90-alpha / 0.743
4egk RDCHeat shock protein HSP 90-alpha / 0.738
1qy8 RDIEndoplasmin / 0.735
2iwu NP5ATP-dependent molecular chaperone HSP82 / 0.733
2yei XQIHeat shock protein HSP 90-alpha / 0.730
2yjw YJWHeat shock protein HSP 90-alpha / 0.727
2xjx XJXHeat shock protein HSP 90-alpha / 0.726
2hkj RDCType 2 DNA topoisomerase 6 subunit B / 0.725
4mpn PV0[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.724
3hhu 819Heat shock protein HSP 90-alpha / 0.723
3k98 1RCHeat shock protein HSP 90-alpha / 0.723
4bqj XKLHeat shock protein HSP 90-alpha / 0.723
3k99 PFTHeat shock protein HSP 90-alpha / 0.720
1u0z RDCEndoplasmin / 0.719
2xd6 XD6ATP-dependent molecular chaperone HSP82 / 0.719
4egh 0OYHeat shock protein HSP 90-alpha / 0.719
2ccu 2D9Heat shock protein HSP 90-alpha / 0.718
3ekr PY9Heat shock protein HSP 90-alpha / 0.718
2byi 2DDHeat shock protein HSP 90-alpha / 0.717
4mpc PV2[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.716
2yi5 YI5Heat shock protein HSP 90-alpha / 0.714
3k97 4CDHeat shock protein HSP 90-alpha / 0.714
3hek BD0Heat shock protein HSP 90-alpha / 0.711
2gfd RDAEndoplasmin / 0.706
2cgf P2NATP-dependent molecular chaperone HSP82 / 0.704
2iwx M1SATP-dependent molecular chaperone HSP82 / 0.695
1yc1 4BCHeat shock protein HSP 90-alpha / 0.692
2byh 2D7Heat shock protein HSP 90-alpha / 0.692
2iws NP4ATP-dependent molecular chaperone HSP82 / 0.691
2uwd 2GGHeat shock protein HSP 90-alpha / 0.690
2xht C0YHeat shock protein HSP 90-alpha / 0.683
2wer RDCATP-dependent molecular chaperone HSP82 / 0.681
2yec XQ0Heat shock protein HSP 90-alpha / 0.680
2bz5 AB4Heat shock protein HSP 90-alpha / 0.674
4ce2 BO5ATP-dependent molecular chaperone HSP82 / 0.669
4ks8 B49Serine/threonine-protein kinase PAK 6 2.7.11.1 0.663
3inx JZCHeat shock protein HSP 90-alpha / 0.662
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
2wcg MT5Glucosylceramidase 3.2.1.45 0.653
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.652
2zmd 537Dual specificity protein kinase TTK 2.7.12.1 0.650
4bqg 50QHeat shock protein HSP 90-alpha / 0.650