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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2xp2 VGH ALK tyrosine kinase receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2xp2 VGHALK tyrosine kinase receptor 2.7.10.1 0.992
4anq VGHALK tyrosine kinase receptor 2.7.10.1 0.967
5aaa VGHALK tyrosine kinase receptor 2.7.10.1 0.964
4ans VGHALK tyrosine kinase receptor 2.7.10.1 0.952
2yfx VGHALK tyrosine kinase receptor 2.7.10.1 0.945
5aab VGHALK tyrosine kinase receptor 2.7.10.1 0.936
5aac VGHALK tyrosine kinase receptor 2.7.10.1 0.915
4ccb OFGALK tyrosine kinase receptor 2.7.10.1 0.847
4cd0 AWJALK tyrosine kinase receptor 2.7.10.1 0.797
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2etk HFSRho-associated protein kinase 1 2.7.11.1 0.676
4ccu AWFALK tyrosine kinase receptor 2.7.10.1 0.675
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.669
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.661
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.654
3rk5 07ZCyclin-dependent kinase 2 2.7.11.22 0.654
1xxj UNCUricase 1.7.3.3 0.651
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.651