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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2x4f 16X Myosin light chain kinase family member 4 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2x4f 16XMyosin light chain kinase family member 4 2.7.11.1 0.850
4e5i 0N9Polymerase acidic protein / 0.744
3uo5 0BXAurora kinase A 2.7.11.1 0.697
4dea NHIAurora kinase A 2.7.11.1 0.681
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.681
1z5m LI83-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.679
4iwq 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 0.677
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.674
3bea IXHMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.673
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.669
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.666
1oec AA2Fibroblast growth factor receptor 2 / 0.660
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.660
3h3c P1EProtein-tyrosine kinase 2-beta 2.7.10.2 0.660
4grb 0XGCasein kinase II subunit alpha 2.7.11.1 0.659
2p2h 994Vascular endothelial growth factor receptor 2 2.7.10.1 0.658
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.657
4ek8 16KCyclin-dependent kinase 2 2.7.11.22 0.650