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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wmw ZYW Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wmw ZYWSerine/threonine-protein kinase Chk1 2.7.11.1 0.927
2wmx ZY6Serine/threonine-protein kinase Chk1 2.7.11.1 0.825
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.768
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2qhm 7CSSerine/threonine-protein kinase Chk1 2.7.11.1 0.690
2ym7 YM7Serine/threonine-protein kinase Chk1 2.7.11.1 0.675
2bfy H1NAurora kinase B-A 2.7.11.1 0.672
2brb PFQSerine/threonine-protein kinase Chk1 2.7.11.1 0.672
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.671
4fsz HK8Serine/threonine-protein kinase Chk1 2.7.11.1 0.667
4oti MI1Serine/threonine-protein kinase N1 / 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4jaj XU1Aurora kinase A 2.7.11.1 0.660
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.659
5dpv SKEAurora kinase A 2.7.11.1 0.658
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.656
4e5w 0NTTyrosine-protein kinase JAK1 / 0.653
4hvs 647Mast/stem cell growth factor receptor Kit 2.7.10.1 0.650