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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wms ZYS Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wms ZYSSerine/threonine-protein kinase Chk1 2.7.11.1 0.837
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3rk9 09ZCyclin-dependent kinase 2 2.7.11.22 0.685
3qqk X02Cyclin-dependent kinase 2 2.7.11.22 0.681
3r8z Z63Cyclin-dependent kinase 2 2.7.11.22 0.676
2vgo AD5Aurora kinase B-A 2.7.11.1 0.670
3qtz X42Cyclin-dependent kinase 2 2.7.11.22 0.669
3rpy 27ZCyclin-dependent kinase 2 2.7.11.22 0.665
3rni 21ZCyclin-dependent kinase 2 2.7.11.22 0.662
4e5f 0N7Polymerase acidic protein / 0.660
3r8u Z31Cyclin-dependent kinase 2 2.7.11.22 0.657
3rzb 02ZCyclin-dependent kinase 2 2.7.11.22 0.654