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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wih P48 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.958
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.749
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.744
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.726
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.717
1oir HDYCyclin-dependent kinase 2 2.7.11.22 0.699
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.695
3i5z Z48Mitogen-activated protein kinase 1 2.7.11.24 0.694
2vv9 IM9Cyclin-dependent kinase 2 2.7.11.22 0.693
2p33 J07Mitogen-activated protein kinase 10 2.7.11.24 0.684
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.684
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.681
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.680
3i4b Z48Glycogen synthase kinase-3 beta 2.7.11.26 0.680
2c5n CK8Cyclin-dependent kinase 2 2.7.11.22 0.678
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.678
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.676
2r3o 2SCCyclin-dependent kinase 2 2.7.11.22 0.666
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.665
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.664
3ddq RRCCyclin-dependent kinase 2 2.7.11.22 0.664
4ek8 16KCyclin-dependent kinase 2 2.7.11.22 0.662
4fv6 E57Mitogen-activated protein kinase 1 2.7.11.24 0.662
1g5s I17Cyclin-dependent kinase 2 2.7.11.22 0.661
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.660
1y91 CT9Cyclin-dependent kinase 2 2.7.11.22 0.659
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.659
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.658
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.657
5ap7 SVEDual specificity protein kinase TTK 2.7.12.1 0.657
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
3dog NNNCyclin-dependent kinase 2 2.7.11.22 0.654
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.654
2r3r 6SCCyclin-dependent kinase 2 2.7.11.22 0.652