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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2v7a 627 Tyrosine-protein kinase ABL1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2v7a 627Tyrosine-protein kinase ABL1 2.7.10.2 0.908
2xba 571ALK tyrosine kinase receptor 2.7.10.1 0.757
2j50 627Aurora kinase A 2.7.11.1 0.745
2wpa 889Cyclin-dependent kinase 2 2.7.11.22 0.695
2bmc MPYAurora kinase A 2.7.11.1 0.690
2j4z 626Aurora kinase A 2.7.11.1 0.679
3zmm F9JTyrosine-protein kinase JAK2 / 0.671
2xyn VX6Abelson tyrosine-protein kinase 2 2.7.10.2 0.663
4qo9 627Serine/threonine-protein kinase 24 2.7.11.1 0.661
2f4j VX6Tyrosine-protein kinase ABL1 2.7.10.2 0.660
4aoj V4ZHigh affinity nerve growth factor receptor 2.7.10.1 0.656
5d12 G97Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.651