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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2qhn 582 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.865
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3nlb 5BESerine/threonine-protein kinase Chk1 2.7.11.1 0.738
4f64 0S8Fibroblast growth factor receptor 1 / 0.737
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.732
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.715
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.712
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.712
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.711
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.691
4nks 2M2Fibroblast growth factor receptor 1 / 0.691
4bdf H3RSerine/threonine-protein kinase Chk2 2.7.11.1 0.680
4f65 0S9Fibroblast growth factor receptor 1 / 0.679
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.674
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.669
4f63 0S7Fibroblast growth factor receptor 1 / 0.664
3w16 P9JAurora kinase A 2.7.11.1 0.662
1zys 199Serine/threonine-protein kinase Chk1 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4e5l DBHPolymerase acidic protein / 0.658
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.656
4b8m VX6Aurora kinase B-A 2.7.11.1 0.654
2e9u A25Serine/threonine-protein kinase Chk1 2.7.11.1 0.652
2x8e X8ESerine/threonine-protein kinase Chk1 2.7.11.1 0.652
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.652
2ym3 YM3Serine/threonine-protein kinase Chk1 2.7.11.1 0.651
4nka 2K7Fibroblast growth factor receptor 1 / 0.651