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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2q36 ATP Actin, alpha skeletal muscle

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2q36 ATPActin, alpha skeletal muscle / 1.098
1qz5 ATPActin, alpha skeletal muscle / 1.088
1s22 ATPActin, alpha skeletal muscle / 1.087
4k41 ATPActin, alpha skeletal muscle / 1.086
1t44 ATPActin, alpha skeletal muscle / 1.072
4pkg ATPActin, alpha skeletal muscle / 1.071
4pki ATPActin, alpha skeletal muscle / 1.059
1c0f ATPMajor actin / 1.046
4b1v ATPActin, alpha skeletal muscle / 1.046
3m1f ATPActin, alpha skeletal muscle / 1.037
4pl8 ATPActin, alpha skeletal muscle / 1.035
1dej ATPMajor actin / 1.033
3w3d ATPActin, gamma-enteric smooth muscle / 1.024
1kxp ATPActin, alpha skeletal muscle / 1.023
4cbx ATPActin-2 / 1.018
1wua ATPActin, alpha skeletal muscle / 1.014
3m6g ATPActin, alpha skeletal muscle / 1.009
1eqy ATPActin, alpha skeletal muscle / 1.002
3mn9 ATPActin-5C / 1.002
1mdu ATPActin, alpha skeletal muscle / 0.999
2q97 ATPActin, alpha skeletal muscle / 0.999
3a5o ATPMajor actin / 0.998
3mn7 ATPActin-5C / 0.998
2a41 ATPActin, alpha skeletal muscle / 0.993
3ffk ATPActin, alpha skeletal muscle / 0.993
2v51 ATPActin, alpha skeletal muscle / 0.983
5ce3 ATPActin / 0.983
3eks ATPActin-5C / 0.982
3mn6 ATPActin-5C / 0.970
1rgi ATPActin, alpha skeletal muscle / 0.966
3eku ATPActin-5C / 0.961
3daw ATPActin, alpha skeletal muscle / 0.958
1nlv ATPMajor actin / 0.955
3chw ATPMajor actin / 0.946
3el2 ATPActin-5C / 0.942
3tu5 ATPActin, alpha skeletal muscle / 0.938
2oan ATPActin, cytoplasmic 1 / 0.923
1atn ATPActin, alpha skeletal muscle / 0.912
1lot ATPActin, alpha skeletal muscle / 0.909
2p9k ATPActin-related protein 2 / 0.891
4pkh ADPActin, alpha skeletal muscle / 0.876
1h1v ATPActin, alpha skeletal muscle / 0.873
4b9q ATPChaperone protein DnaK / 0.865
3wt0 ATPCell division protein FtsA / 0.860
4ehu ANP2-hydroxyisocaproyl-CoA dehydratase activator / 0.858
3a5m ATPMajor actin / 0.848
4m63 ATPActin-5C / 0.848
4ci6 ATPActin / 0.847
1rfq ATPActin, alpha skeletal muscle / 0.799
4k42 ADPActin, alpha skeletal muscle / 0.798
1ijj ATPActin, alpha skeletal muscle / 0.795
1yxq ATPActin, alpha skeletal muscle / 0.793
4eht ADP2-hydroxyisocaproyl-CoA dehydratase activator / 0.790
3wqt ANPCell division protein FtsA / 0.769
1nmd ATPMajor actin / 0.765
4k43 ADPActin, alpha skeletal muscle / 0.753
2e2q ADPATP-dependent hexokinase / 0.743
4a61 ANPPlasmid segregation protein ParM / 0.742
4jhd ANPActin-5C / 0.737
5bsm ATP4-coumarate--CoA ligase 2 6.2.1.12 0.736
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.729
2zgz GNPPlasmid segregation protein ParM / 0.726
4bri UNPEctonucleoside triphosphate diphosphohydrolase I / 0.726
1nm1 ATPMajor actin / 0.718
4a62 ANPPlasmid segregation protein ParM / 0.715
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.711
2zgy GDPPlasmid segregation protein ParM / 0.708
4nke RISFarnesyl pyrophosphate synthase 2.5.1.10 0.694
1mwm ADPPlasmid segregation protein ParM / 0.689
3u9d ATPActin, alpha skeletal muscle / 0.689
3ule ATPActin-related protein 2 / 0.689
4iij GTPTubulin alpha-1B chain / 0.688
2d0o ADPDiol dehydratase-reactivating factor alpha subunit / 0.686
3wqu ATPCell division protein FtsA / 0.679
4xjx ATPType I restriction enzyme EcoR124II R protein 3.1.21.3 0.677
2fsn ADPArchaeal actin homolog / 0.676
1zbd GTPRas-related protein Rab-3A / 0.674
2a84 ATPPantothenate synthetase 6.3.2.1 0.673
4xjc TTPdCTP deaminase / 0.673
1yv5 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.670
3ryh GTPTubulin alpha chain / 0.667
4dwb 0M7Farnesyl pyrophosphate synthase / 0.666
3u4l ATPActin, cytoplasmic 1 / 0.665
4ihj GTPTubulin alpha-1B chain / 0.662
4fvq ATPTyrosine-protein kinase JAK2 / 0.661
3orl AGSSerine/threonine protein kinase / 0.660
5itz GTPTubulin alpha-1B chain / 0.660
3ez3 IPEFarnesyl pyrophosphate synthase, putative / 0.659
2pz8 APCNH(3)-dependent NAD(+) synthetase / 0.658
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.657
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.656
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.656
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.656
2x60 GTPMannose-1-phosphate guanylyltransferase / 0.656
3zcb ATPAdenosine monophosphate-protein transferase VbhT 2.7.7.n1 0.656
4dxj 0M9Farnesyl pyrophosphate synthase / 0.656
1yq7 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.654
2qzs ADPGlycogen synthase 2.4.1.21 0.654
4ymv ATPABC-type polar amino acid transport system, ATPase component / 0.653
2qmz LDPRibosyldihydronicotinamide dehydrogenase [quinone] / 0.652
2r4u ADPGlycogen synthase 2.4.1.21 0.652
4du6 GTPGTP cyclohydrolase 1 / 0.652
1sxj AGSReplication factor C subunit 1 / 0.651