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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pit DHT Androgen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pit DHTAndrogen receptor / 1.206
2pio DHTAndrogen receptor / 1.164
1t7r DHTAndrogen receptor / 1.150
1t73 DHTAndrogen receptor / 1.139
2piu DHTAndrogen receptor / 1.138
1t74 DHTAndrogen receptor / 1.136
2pip DHTAndrogen receptor / 1.133
1t5z DHTAndrogen receptor / 1.130
4oey DHTAndrogen receptor / 1.126
2ama DHTAndrogen receptor / 1.125
4oea DHTAndrogen receptor / 1.123
2piw DHTAndrogen receptor / 1.118
4oez DHTAndrogen receptor / 1.116
1t79 DHTAndrogen receptor / 1.115
4ofr DHTAndrogen receptor / 1.111
2piq DHTAndrogen receptor / 1.103
2pkl DHTAndrogen receptor / 1.095
1t65 DHTAndrogen receptor / 1.079
2pix DHTAndrogen receptor / 1.074
4oed DHTAndrogen receptor / 1.074
1t76 DHTAndrogen receptor / 1.072
1t7f DHTAndrogen receptor / 1.063
2z4j DHTAndrogen receptor / 1.019
2ylp TESAndrogen receptor / 1.009
2q7i TESAndrogen receptor / 1.000
2am9 TESAndrogen receptor / 0.995
1t7m DHTAndrogen receptor / 0.990
2q7k TESAndrogen receptor / 0.976
2q7l TESAndrogen receptor / 0.976
2ylq TESAndrogen receptor / 0.965
4hlw TESAndrogen receptor / 0.951
1t7t DHTAndrogen receptor / 0.925
2piv DHTAndrogen receptor / 0.900
1t63 DHTAndrogen receptor / 0.870
2ao6 R18Androgen receptor / 0.863
2pir DHTAndrogen receptor / 0.832
4ofu DHTAndrogen receptor / 0.827
1xow R18Androgen receptor / 0.821
1xj7 DHTAndrogen receptor / 0.819
2pnu ENMAndrogen receptor / 0.806
4e5l DBHPolymerase acidic protein / 0.764
1gs4 ZK5Androgen receptor / 0.757
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2q7j TESAndrogen receptor / 0.740
2yhd TESAndrogen receptor / 0.732
1xq3 R18Androgen receptor / 0.727
1lhn AONSex hormone-binding globulin / 0.722
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.713
2qpy DHTAndrogen receptor / 0.712
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.706
2p15 EZTEstrogen receptor / 0.706
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.701
1lho AOMSex hormone-binding globulin / 0.700
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.696
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.696
4qe6 JN3Bile acid receptor / 0.695
2ylo TESAndrogen receptor / 0.694
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.694
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.693
4k7a DHTAndrogen receptor / 0.692
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.690
4q0a 4OAVitamin D3 receptor A / 0.689
2d09 FLVBiflaviolin synthase CYP158A2 / 0.680
1lri CLRBeta-elicitin cryptogein / 0.671
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.664
2j7x ESTEstrogen receptor beta / 0.662
2g5o DRQEstrogen receptor / 0.661
1sqn NDRProgesterone receptor / 0.657
3gyt DL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily / 0.656
2aax PDNMineralocorticoid receptor / 0.655
3w5r LOAVitamin D3 receptor / 0.655
4dvq 1CACytochrome P450 11B2, mitochondrial 1.14.15.4 0.655
1irj CPSProtein S100-A9 / 0.651
4ple CPSNuclear receptor subfamily 5 group A member 2 / 0.650