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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pip DHT Androgen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pip DHTAndrogen receptor / 1.192
1t74 DHTAndrogen receptor / 1.164
2pio DHTAndrogen receptor / 1.162
2pit DHTAndrogen receptor / 1.133
1t73 DHTAndrogen receptor / 1.120
1t79 DHTAndrogen receptor / 1.116
1t7r DHTAndrogen receptor / 1.115
2piw DHTAndrogen receptor / 1.114
2pkl DHTAndrogen receptor / 1.114
1t5z DHTAndrogen receptor / 1.111
2ama DHTAndrogen receptor / 1.111
2piv DHTAndrogen receptor / 1.111
1t76 DHTAndrogen receptor / 1.107
1t7f DHTAndrogen receptor / 1.106
4oez DHTAndrogen receptor / 1.102
2piq DHTAndrogen receptor / 1.096
4oey DHTAndrogen receptor / 1.091
4oea DHTAndrogen receptor / 1.089
1t7m DHTAndrogen receptor / 1.077
1t65 DHTAndrogen receptor / 1.074
4ofr DHTAndrogen receptor / 1.073
1t63 DHTAndrogen receptor / 1.049
2qpy DHTAndrogen receptor / 1.046
2z4j DHTAndrogen receptor / 1.024
2pix DHTAndrogen receptor / 1.021
2q7i TESAndrogen receptor / 0.995
1xj7 DHTAndrogen receptor / 0.984
2ylp TESAndrogen receptor / 0.976
2q7k TESAndrogen receptor / 0.965
4oed DHTAndrogen receptor / 0.960
2q7l TESAndrogen receptor / 0.959
2pnu ENMAndrogen receptor / 0.938
4hlw TESAndrogen receptor / 0.901
2ao6 R18Androgen receptor / 0.848
2q7j TESAndrogen receptor / 0.840
2am9 TESAndrogen receptor / 0.821
1gs4 ZK5Androgen receptor / 0.791
2ylq TESAndrogen receptor / 0.789
1xow R18Androgen receptor / 0.787
1t7t DHTAndrogen receptor / 0.785
4e5l DBHPolymerase acidic protein / 0.769
2yhd TESAndrogen receptor / 0.767
4ofu DHTAndrogen receptor / 0.765
1xq3 R18Androgen receptor / 0.752
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.725
4pxm ESTEstrogen receptor / 0.722
2pir DHTAndrogen receptor / 0.721
2j7x ESTEstrogen receptor beta / 0.709
3zqt TESAndrogen receptor / 0.700
2ylo TESAndrogen receptor / 0.699
2piu DHTAndrogen receptor / 0.696
4k7a DHTAndrogen receptor / 0.693
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.691
4qe6 JN3Bile acid receptor / 0.691
1lri CLRBeta-elicitin cryptogein / 0.682
1lhn AONSex hormone-binding globulin / 0.680
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.677
1osv CHCBile acid receptor / 0.676
2d09 FLVBiflaviolin synthase CYP158A2 / 0.676
4c49 HCYCorticosteroid-binding globulin / 0.676
2p15 EZTEstrogen receptor / 0.672
1e3k R18Progesterone receptor / 0.671
4q0a 4OAVitamin D3 receptor A / 0.670
3iw1 ASDSteroid C26-monooxygenase 1.14.13.141 0.664
1xf0 ASDAldo-keto reductase family 1 member C3 / 0.663
4apu A2KProgesterone receptor / 0.661
2yja ESTEstrogen receptor / 0.656
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.655
3g1r FIT3-oxo-5-beta-steroid 4-dehydrogenase / 0.654
1y9r 1CAMineralocorticoid receptor / 0.653
2wuu NHWGlycylpeptide N-tetradecanoyltransferase / 0.653
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 0.653
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.652
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.651
2aa7 1CAMineralocorticoid receptor / 0.651