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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdx ZST Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pdx ZSTAldose reductase 1.1.1.21 1.189
2dux ZSTAldose reductase 1.1.1.21 1.012
2hv5 ZSTAldose reductase 1.1.1.21 0.998
2fz9 ZSTAldose reductase 1.1.1.21 0.997
3m0i ZSTAldose reductase 1.1.1.21 0.980
2fz8 ZSTAldose reductase 1.1.1.21 0.974
2pdi ZSTAldose reductase 1.1.1.21 0.972
2pdb ZSTAldose reductase 1.1.1.21 0.964
2pd5 ZSTAldose reductase 1.1.1.21 0.945
2pdm ZSTAldose reductase 1.1.1.21 0.942
3len ZSTAldose reductase 1.1.1.21 0.908
2hvn ZSTAldose reductase 1.1.1.21 0.901
2pdq 47DAldose reductase 1.1.1.21 0.873
3mb9 ZSTAldose reductase 1.1.1.21 0.873
2pdh 47DAldose reductase 1.1.1.21 0.871
2duz ZSTAldose reductase 1.1.1.21 0.870
2pdn 47DAldose reductase 1.1.1.21 0.865
2dv0 ZSTAldose reductase 1.1.1.21 0.862
2hvo ZSTAldose reductase 1.1.1.21 0.857
4gca 2X9Aldose reductase 1.1.1.21 0.855
2pdg 47DAldose reductase 1.1.1.21 0.839
2pdf ZSTAldose reductase 1.1.1.21 0.790
2pdp 393Aldose reductase 1.1.1.21 0.788
2pdc 393Aldose reductase 1.1.1.21 0.775
2ikj 393Aldose reductase 1.1.1.21 0.768
1z3n 3NAAldose reductase 1.1.1.21 0.758
3g5e Q74Aldose reductase 1.1.1.21 0.744
2pdj 393Aldose reductase 1.1.1.21 0.738
1frb ZSTAldose reductase-related protein 2 / 0.735
3t42 3T4Aldose reductase 1.1.1.21 0.724
1t41 ID5Aldose reductase 1.1.1.21 0.723
2i17 LDTAldose reductase 1.1.1.21 0.722
3lz5 LDTAldose reductase 1.1.1.21 0.719
3m4h 388Aldose reductase 1.1.1.21 0.714
1t40 ID5Aldose reductase 1.1.1.21 0.708
3lql LDTAldose reductase 1.1.1.21 0.700
2iki 388Aldose reductase 1.1.1.21 0.694
2pzn 393Aldose reductase 1.1.1.21 0.694
3m64 393Aldose reductase 1.1.1.21 0.694
2iqd LPAAldose reductase 1.1.1.21 0.681
3mc5 393Aldose reductase 1.1.1.21 0.679
2pdu 393Aldose reductase 1.1.1.21 0.678
2nvc ITAAldose reductase 1.1.1.21 0.675
1iei ZESAldose reductase 1.1.1.21 0.674
3ghr LDTAldose reductase 1.1.1.21 0.665
3s3g TLTAldose reductase 1.1.1.21 0.662
2i16 LDTAldose reductase 1.1.1.21 0.658
2qxw LDTAldose reductase 1.1.1.21 0.658
3ghs LDTAldose reductase 1.1.1.21 0.658
2is7 2CLAldose reductase 1.1.1.21 0.656
1us0 LDTAldose reductase 1.1.1.21 0.650