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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdn 47D Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pdn 47DAldose reductase 1.1.1.21 1.129
3mb9 ZSTAldose reductase 1.1.1.21 1.029
2pdm ZSTAldose reductase 1.1.1.21 1.012
2pdg 47DAldose reductase 1.1.1.21 1.005
4gca 2X9Aldose reductase 1.1.1.21 0.994
2hvo ZSTAldose reductase 1.1.1.21 0.993
2duz ZSTAldose reductase 1.1.1.21 0.989
2pdh 47DAldose reductase 1.1.1.21 0.983
2dux ZSTAldose reductase 1.1.1.21 0.970
2fz9 ZSTAldose reductase 1.1.1.21 0.958
3m0i ZSTAldose reductase 1.1.1.21 0.931
2dv0 ZSTAldose reductase 1.1.1.21 0.925
3g5e Q74Aldose reductase 1.1.1.21 0.910
2pd5 ZSTAldose reductase 1.1.1.21 0.899
1z3n 3NAAldose reductase 1.1.1.21 0.868
2pdx ZSTAldose reductase 1.1.1.21 0.865
1frb ZSTAldose reductase-related protein 2 / 0.801
2hv5 ZSTAldose reductase 1.1.1.21 0.800
2pdf ZSTAldose reductase 1.1.1.21 0.769
1t40 ID5Aldose reductase 1.1.1.21 0.760
2pdj 393Aldose reductase 1.1.1.21 0.753
2pdc 393Aldose reductase 1.1.1.21 0.752
2pdp 393Aldose reductase 1.1.1.21 0.745
2ikj 393Aldose reductase 1.1.1.21 0.726
2pzn 393Aldose reductase 1.1.1.21 0.726
3ld5 LDTAldose reductase 1.1.1.21 0.716
3lql LDTAldose reductase 1.1.1.21 0.711
3ghu LDTAldose reductase 1.1.1.21 0.710
3ght LDTAldose reductase 1.1.1.21 0.699
2fz8 ZSTAldose reductase 1.1.1.21 0.695
3len ZSTAldose reductase 1.1.1.21 0.695
3mc5 393Aldose reductase 1.1.1.21 0.695
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.688
2pdi ZSTAldose reductase 1.1.1.21 0.684
3ghs LDTAldose reductase 1.1.1.21 0.684
3lbo LDTAldose reductase 1.1.1.21 0.683
2pdb ZSTAldose reductase 1.1.1.21 0.681
2hvn ZSTAldose reductase 1.1.1.21 0.680
2pdu 393Aldose reductase 1.1.1.21 0.680
3ghr LDTAldose reductase 1.1.1.21 0.679
3lz5 LDTAldose reductase 1.1.1.21 0.677
3t42 3T4Aldose reductase 1.1.1.21 0.677
2qxw LDTAldose reductase 1.1.1.21 0.662
3m64 393Aldose reductase 1.1.1.21 0.662
4yu1 53NAldose reductase 1.1.1.21 0.660
1t41 ID5Aldose reductase 1.1.1.21 0.658
2inz OHPAldose reductase 1.1.1.21 0.657
2pdq 47DAldose reductase 1.1.1.21 0.653
2nni MTKCytochrome P450 2C8 / 0.650