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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdk SBI Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pdk SBIAldose reductase 1.1.1.21 0.836
2pdw FIDAldose reductase 1.1.1.21 0.784
2pdy FIDAldose reductase 1.1.1.21 0.783
1pwm FIDAldose reductase 1.1.1.21 0.773
1ef3 FIDAldose reductase 1.1.1.21 0.766
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2pd9 FIDAldose reductase 1.1.1.21 0.725
4ga8 SBIAldo-keto reductase family 1 member B10 1.1.1 0.720
4gab FIDAldo-keto reductase family 1 member B10 1.1.1 0.716
2agt FIDAldose reductase 1.1.1.21 0.714
3h4g FIDAlcohol dehydrogenase [NADP(+)] 1.1.1.2 0.713
1ah0 SBIAldose reductase 1.1.1.21 0.681
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.663
4e5f 0N7Polymerase acidic protein / 0.660