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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdh 47D Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2pdh 47DAldose reductase 1.1.1.21 1.105
2pdn 47DAldose reductase 1.1.1.21 0.983
2pd5 ZSTAldose reductase 1.1.1.21 0.947
2dv0 ZSTAldose reductase 1.1.1.21 0.922
2pdm ZSTAldose reductase 1.1.1.21 0.920
3g5e Q74Aldose reductase 1.1.1.21 0.914
2pdg 47DAldose reductase 1.1.1.21 0.906
4gca 2X9Aldose reductase 1.1.1.21 0.884
2dux ZSTAldose reductase 1.1.1.21 0.881
2pdf ZSTAldose reductase 1.1.1.21 0.881
2pdx ZSTAldose reductase 1.1.1.21 0.871
2hvo ZSTAldose reductase 1.1.1.21 0.860
2pdq 47DAldose reductase 1.1.1.21 0.856
1frb ZSTAldose reductase-related protein 2 / 0.827
2hv5 ZSTAldose reductase 1.1.1.21 0.804
3len ZSTAldose reductase 1.1.1.21 0.791
3mb9 ZSTAldose reductase 1.1.1.21 0.779
3m0i ZSTAldose reductase 1.1.1.21 0.754
2fz9 ZSTAldose reductase 1.1.1.21 0.753
2pdb ZSTAldose reductase 1.1.1.21 0.753
3lbo LDTAldose reductase 1.1.1.21 0.744
2pdj 393Aldose reductase 1.1.1.21 0.741
2pdc 393Aldose reductase 1.1.1.21 0.735
2ikj 393Aldose reductase 1.1.1.21 0.734
2duz ZSTAldose reductase 1.1.1.21 0.733
2pdp 393Aldose reductase 1.1.1.21 0.730
3ld5 LDTAldose reductase 1.1.1.21 0.730
3lql LDTAldose reductase 1.1.1.21 0.730
3ghu LDTAldose reductase 1.1.1.21 0.720
3m4h 388Aldose reductase 1.1.1.21 0.717
3lz5 LDTAldose reductase 1.1.1.21 0.712
2fz8 ZSTAldose reductase 1.1.1.21 0.709
1t40 ID5Aldose reductase 1.1.1.21 0.706
2pzn 393Aldose reductase 1.1.1.21 0.694
2hvn ZSTAldose reductase 1.1.1.21 0.693
3m64 393Aldose reductase 1.1.1.21 0.693
2pdu 393Aldose reductase 1.1.1.21 0.690
4yu1 53NAldose reductase 1.1.1.21 0.689
2pdi ZSTAldose reductase 1.1.1.21 0.684
3t42 3T4Aldose reductase 1.1.1.21 0.684
2qxw LDTAldose reductase 1.1.1.21 0.671
3ghr LDTAldose reductase 1.1.1.21 0.671
3ghs LDTAldose reductase 1.1.1.21 0.671
3ght LDTAldose reductase 1.1.1.21 0.665
3mc5 393Aldose reductase 1.1.1.21 0.660
1us0 LDTAldose reductase 1.1.1.21 0.651
2i16 LDTAldose reductase 1.1.1.21 0.651
2i17 LDTAldose reductase 1.1.1.21 0.651