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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2jko BIJ Focal adhesion kinase 1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.994
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.761
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.759
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.759
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.753
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.732
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.717
3elj GS7Mitogen-activated protein kinase 8 2.7.11.24 0.715
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.714
1y57 MPZProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.710
3rni 21ZCyclin-dependent kinase 2 2.7.11.22 0.692
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.687
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.683
4dea NHIAurora kinase A 2.7.11.1 0.683
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.682
3rk7 08ZCyclin-dependent kinase 2 2.7.11.22 0.681
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.681
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.678
1oec AA2Fibroblast growth factor receptor 2 / 0.675
2euf LQQCyclin-dependent kinase 6 2.7.11.22 0.668
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.667
3rpy 27ZCyclin-dependent kinase 2 2.7.11.22 0.666
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.666
3o0g 3O0Cyclin-dependent-like kinase 5 2.7.11.1 0.661
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.659
2wxv WXVCyclin-dependent kinase 2 2.7.11.22 0.658
3med 65BGag-Pol polyprotein 2.7.7.49 0.657
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.657
2iw6 QQ2Cyclin-dependent kinase 2 2.7.11.22 0.654
4aot GW8Serine/threonine-protein kinase 10 2.7.11.1 0.654
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.653
3nup 3NUCyclin-dependent kinase 6 2.7.11.22 0.652
3rk5 07ZCyclin-dependent kinase 2 2.7.11.22 0.652
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.651
2xch CKG3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
3uo5 0BXAurora kinase A 2.7.11.1 0.651
4b99 R4LMitogen-activated protein kinase 7 2.7.11.24 0.651
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.651