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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ivv PP1 Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ivv PP1Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.960
1qcf PP1Tyrosine-protein kinase HCK 2.7.10.2 0.791
4e5i 0N9Polymerase acidic protein / 0.744
2ivu ZD6Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.738
4d9t 0JGRibosomal protein S6 kinase alpha-3 2.7.11.1 0.726
1qpe PP2Tyrosine-protein kinase Lck 2.7.10.2 0.720
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.714
4k11 0J9Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.704
2c0t L3GTyrosine-protein kinase HCK 2.7.10.2 0.699
3vs5 VSGTyrosine-protein kinase HCK 2.7.10.2 0.691
4yuq KS1Calmodulin-like domain protein kinase / 0.680
5f0a 1FBcGMP-dependent protein kinase, putative / 0.676
4lgg VGGProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.674
3vs2 VSBTyrosine-protein kinase HCK 2.7.10.2 0.665
3mwu BK3Calmodulin-domain protein kinase 1, putative / 0.664
4dgg I76Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.664
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.662
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.662
4e5f 0N7Polymerase acidic protein / 0.660
4otw DB8Receptor tyrosine-protein kinase erbB-3 2.7.10.1 0.660
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
3ncg BK1Calmodulin-domain protein kinase 1, putative / 0.654