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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2itn ANP Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.860
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.733
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.733
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.702
2pml ANPUncharacterized protein / 0.697
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.689
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.686
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.683
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.683
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.673
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.673
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.670
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.670
4o1p ANPRibonuclease L / 0.669
4q5j ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.669
5eg3 ACPFibroblast growth factor receptor 2 / 0.669
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.668
4riy ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.668
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.667
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.666
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.666
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.666
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
3blq ATPCyclin-dependent kinase 9 2.7.11.22 0.659
4k2r ANPTyrosine-protein kinase ZAP-70 2.7.10.2 0.658
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.657
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
2pbz ATPUncharacterized protein / 0.656
1wbp ADPSRSF protein kinase 1 2.7.11.1 0.655
2olc ADPMethylthioribose kinase 2.7.1.100 0.655
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.655
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.654
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.653
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
3akl ANPSerine/threonine-protein kinase CtkA 2.7.11.1 0.652
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.652
5ckw ANPUncharacterized protein / 0.651
5l6w AGSLIM domain kinase 1 2.7.11.1 0.650