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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ikj 393 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ikj 393Aldose reductase 1.1.1.21 1.039
3m64 393Aldose reductase 1.1.1.21 1.033
2pzn 393Aldose reductase 1.1.1.21 0.998
2pdc 393Aldose reductase 1.1.1.21 0.982
3mc5 393Aldose reductase 1.1.1.21 0.958
2pdj 393Aldose reductase 1.1.1.21 0.953
3t42 3T4Aldose reductase 1.1.1.21 0.918
2pdp 393Aldose reductase 1.1.1.21 0.905
3ld5 LDTAldose reductase 1.1.1.21 0.886
3ghu LDTAldose reductase 1.1.1.21 0.876
3lbo LDTAldose reductase 1.1.1.21 0.873
2qxw LDTAldose reductase 1.1.1.21 0.870
3ghr LDTAldose reductase 1.1.1.21 0.856
3ghs LDTAldose reductase 1.1.1.21 0.856
3ght LDTAldose reductase 1.1.1.21 0.856
3m4h 388Aldose reductase 1.1.1.21 0.855
3lql LDTAldose reductase 1.1.1.21 0.854
2i16 LDTAldose reductase 1.1.1.21 0.852
2i17 LDTAldose reductase 1.1.1.21 0.852
1us0 LDTAldose reductase 1.1.1.21 0.851
2pdu 393Aldose reductase 1.1.1.21 0.846
3lz5 LDTAldose reductase 1.1.1.21 0.838
2pdm ZSTAldose reductase 1.1.1.21 0.815
2iki 388Aldose reductase 1.1.1.21 0.812
2hv5 ZSTAldose reductase 1.1.1.21 0.800
3m0i ZSTAldose reductase 1.1.1.21 0.790
4yu1 53NAldose reductase 1.1.1.21 0.776
2pdx ZSTAldose reductase 1.1.1.21 0.768
1t40 ID5Aldose reductase 1.1.1.21 0.764
4gca 2X9Aldose reductase 1.1.1.21 0.746
1z3n 3NAAldose reductase 1.1.1.21 0.741
2pdh 47DAldose reductase 1.1.1.21 0.734
2pd5 ZSTAldose reductase 1.1.1.21 0.727
2pdn 47DAldose reductase 1.1.1.21 0.726
2pdf ZSTAldose reductase 1.1.1.21 0.722
2dux ZSTAldose reductase 1.1.1.21 0.717
2hvo ZSTAldose reductase 1.1.1.21 0.717
1iei ZESAldose reductase 1.1.1.21 0.714
2inz OHPAldose reductase 1.1.1.21 0.714
2ikh LITAldose reductase 1.1.1.21 0.709
3mb9 ZSTAldose reductase 1.1.1.21 0.704
3s3g TLTAldose reductase 1.1.1.21 0.701
2duz ZSTAldose reductase 1.1.1.21 0.697
2is7 2CLAldose reductase 1.1.1.21 0.693
1z89 62PAldose reductase 1.1.1.21 0.692
2nvc ITAAldose reductase 1.1.1.21 0.692
2pdb ZSTAldose reductase 1.1.1.21 0.691
3g5e Q74Aldose reductase 1.1.1.21 0.689
2iqd LPAAldose reductase 1.1.1.21 0.686
2pdq 47DAldose reductase 1.1.1.21 0.686
2fz9 ZSTAldose reductase 1.1.1.21 0.683
2hvn ZSTAldose reductase 1.1.1.21 0.683
2fz8 ZSTAldose reductase 1.1.1.21 0.682
3len ZSTAldose reductase 1.1.1.21 0.681
2pdg 47DAldose reductase 1.1.1.21 0.677
2pdi ZSTAldose reductase 1.1.1.21 0.676
1zua TOLAldo-keto reductase family 1 member B10 1.1.1 0.675
1t41 ID5Aldose reductase 1.1.1.21 0.672
1ah3 TOLAldose reductase 1.1.1.21 0.671
2fzd TOLAldose reductase 1.1.1.21 0.663
2pdl TOLAldose reductase 1.1.1.21 0.662
1frb ZSTAldose reductase-related protein 2 / 0.653