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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2i17 LDT Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2i17 LDTAldose reductase 1.1.1.21 1.124
2i16 LDTAldose reductase 1.1.1.21 1.123
1us0 LDTAldose reductase 1.1.1.21 1.122
3ghr LDTAldose reductase 1.1.1.21 1.106
3ghs LDTAldose reductase 1.1.1.21 1.102
2qxw LDTAldose reductase 1.1.1.21 1.101
3lbo LDTAldose reductase 1.1.1.21 1.060
3ght LDTAldose reductase 1.1.1.21 1.048
3ghu LDTAldose reductase 1.1.1.21 1.046
3lz5 LDTAldose reductase 1.1.1.21 1.043
3ld5 LDTAldose reductase 1.1.1.21 1.040
3lql LDTAldose reductase 1.1.1.21 1.022
3m4h 388Aldose reductase 1.1.1.21 0.960
2iki 388Aldose reductase 1.1.1.21 0.943
2ikj 393Aldose reductase 1.1.1.21 0.852
2pdj 393Aldose reductase 1.1.1.21 0.806
1iei ZESAldose reductase 1.1.1.21 0.802
2pdc 393Aldose reductase 1.1.1.21 0.801
3t42 3T4Aldose reductase 1.1.1.21 0.797
3m64 393Aldose reductase 1.1.1.21 0.793
2pzn 393Aldose reductase 1.1.1.21 0.775
2pdp 393Aldose reductase 1.1.1.21 0.768
3mc5 393Aldose reductase 1.1.1.21 0.763
2pdu 393Aldose reductase 1.1.1.21 0.731
2pdx ZSTAldose reductase 1.1.1.21 0.722
4gca 2X9Aldose reductase 1.1.1.21 0.718
1t40 ID5Aldose reductase 1.1.1.21 0.715
2pdq 47DAldose reductase 1.1.1.21 0.700
2hvn ZSTAldose reductase 1.1.1.21 0.698
2inz OHPAldose reductase 1.1.1.21 0.692
3s3g TLTAldose reductase 1.1.1.21 0.681
1frb ZSTAldose reductase-related protein 2 / 0.673
2nvc ITAAldose reductase 1.1.1.21 0.673
2pdi ZSTAldose reductase 1.1.1.21 0.670
2fzd TOLAldose reductase 1.1.1.21 0.669
2fz9 ZSTAldose reductase 1.1.1.21 0.668
2iqd LPAAldose reductase 1.1.1.21 0.668
3m0i ZSTAldose reductase 1.1.1.21 0.666
2dv0 ZSTAldose reductase 1.1.1.21 0.662
1pwl BFIAldose reductase 1.1.1.21 0.659
2ipw 2CLAldose reductase 1.1.1.21 0.656
4yu1 53NAldose reductase 1.1.1.21 0.653
2pdh 47DAldose reductase 1.1.1.21 0.651