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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hy8 1ST Serine/threonine-protein kinase PAK 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.963
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.812
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.787
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.770
1xjd STUProtein kinase C theta type 2.7.11.13 0.749
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.748
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.741
2in6 839Wee1-like protein kinase 2.7.10.2 0.737
3biz 61EWee1-like protein kinase 2.7.10.2 0.735
3bi6 396Wee1-like protein kinase 2.7.10.2 0.732
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.727
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.726
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.717
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.712
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
2z2w 770Wee1-like protein kinase 2.7.10.2 0.704
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.693
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.682
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.673
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.672
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.671
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.667
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.666
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.665
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.663
4e6d 0NUTyrosine-protein kinase JAK2 / 0.657
1byg STUTyrosine-protein kinase CSK / 0.655
3cqe P91Wee1-like protein kinase 2.7.10.2 0.654
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.653
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4agu D15Cyclin-dependent kinase-like 1 / 0.650