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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2hxq 373 Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2hxq 373Serine/threonine-protein kinase Chk1 2.7.11.1 0.899
2hy0 306Serine/threonine-protein kinase Chk1 2.7.11.1 0.861
4fsr HKCSerine/threonine-protein kinase Chk1 2.7.11.1 0.748
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.746
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2e9o A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.738
2gdo 12CSerine/threonine-protein kinase Chk1 2.7.11.1 0.731
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.728
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.728
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.712
4fsm HK1Serine/threonine-protein kinase Chk1 2.7.11.1 0.693
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.689
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.683
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.682
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.677
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.676
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.676
2uzw SS4cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
2c3l IDZSerine/threonine-protein kinase Chk1 2.7.11.1 0.666
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.666
2m3z 1HFGag-Pol polyprotein / 0.664
4e5f 0N7Polymerase acidic protein / 0.660
3oog YTPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.658
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.657
2y7j B49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.7.11.19 0.657
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.655
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.653
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.653
2cdz 23DSerine/threonine-protein kinase PAK 4 2.7.11.1 0.653
2wmt ZYTSerine/threonine-protein kinase Chk1 2.7.11.1 0.653
1uv5 BRWGlycogen synthase kinase-3 beta 2.7.11.26 0.652
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.652
2ye4 2FYHeat shock protein HSP 90-alpha / 0.652
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
3e5a VX6Aurora kinase A 2.7.11.1 0.651
4agd B49Vascular endothelial growth factor receptor 2 2.7.10.1 0.650